Health Condition 1: P84- Other problems with newborn
Conditions
Interventions
Intervention1: Subcutaneous injection of Nitroglycerin before radial artery cannulation: Nitroglycerin 5mcg/kg diluted to a total concentration of 0.1 ml/kg will be given only once over 10 seconds in
Sponsors
Postgraduate Institute of Medical Education and Research (PGIMER)
Eligibility
Inclusion criteria
Inclusion criteria: Neonates with postconceptual age greater than 34 weeks and weight greater than 2 kg and those scheduled for major elective or emergency surgery under general anaesthesia
Exclusion criteria
Exclusion criteria: neonates with congenital heart disease, any know hypersensitivity or contraindication to Nitroglycerin, wound infection or hematomas at the site of cannulation, known coagulation abnormality, suspected hydrocephalus or raised intracranial pressure, neonates with syndromic facies, known connective tissue disorder and refusal of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| First attempt success rate of radial artery cannulationTimepoint: At the first attempt of radial artery cannulation, at the completion of radial artery cannulation | — |
Secondary
| Measure | Time frame |
|---|---|
| Diameter of radial aretryTimepoint: Before injecting the test drug, 3 minutes after injecting the test drug and Post cannulation;Number of attempts to cannulate radial arteryTimepoint: After successful cannulation of radial artery;Overall procedure timeTimepoint: After successful cannulation of radial artery;Incidence of VasospasmTimepoint: After cannulation of radial artery;Incidence of hematomaTimepoint: After cannulation of radial artery;Incidence of HypotensionTimepoint: Baseline and thereafter every two minutes and upto 20 minutes after injection of the study drug | — |
Countries
India
Contacts
Public ContactPreethy J Mathew
Postgraduate Institute Of Medical Education and Research(PGIMER)
Outcome results
None listed