Combined effect of locally injected Vitamin D3 and injectable platelet rich fibrin which is a blood derivative on the rate of tooth movement during comprehensive orthodontic treatment in adult patients and expression of various biomarkers present in gingival crevicular fluid

Synergistic Effect of Locally Injected Vitamin D3 and Injectable Platelet Rich Fibrin (i-PRF) on the Rate of Maxillary Canine Retraction, and Expression of Various Biomarkers in Gingival Crevicular Fluid (GCF) During Comprehensive Orthodontic Treatment: A Randomized Split Mouth Comparative Study - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/100911

Enrollment

Registered

2026-01-12

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K089- Disorder of teeth and supporting structures, unspecified Health Condition 2: 8- Other Procedures

Interventions

Intervention1: i-prf and vitamin D injection : Injecting vitamin D 1ml at two points buccally along the distal margin of the root of canine, 1cm above the CEJ and at the buccal vestibule. 1ml at two p

Eligibility

Inclusion criteria

Inclusion criteria: Class I bimaxillary dentoalveolar protrusion or Class II div 1 malocclusion and minimum crowding and spacing, either all 1st premolars or only upper 1st premolars extraction. Presence of full complement of teeth in the maxillary arch except 3rd molars. Good oral hygiene

Exclusion criteria

Exclusion criteria: Patients who are not willing to participate in the study, History of complete or incomplete comprehensive orthodontic treatment, Subject who fails to maintain adequate oral hygiene all through the orthodontic treatment, Subjects with pregnancy, Subjects having any known syndrome or metabolic disorder affecting calcium and phosphate metabolism, Subjects on long-term medication like NSAID S or steroids, Lack of manual dexterity.

Design outcomes

Primary

Measure	Time frame
To estimate the synergistic effects of localized Vitamin D and i-PRF injections on the rate of maxillary canine retraction during comprehensive orthodontic treatmentTimepoint: 8 weeks	—

Secondary

Measure	Time frame
1)To evaluate the effects of Vitamin D3 & i-PRF injection on the concentration of various biomarkers in GCF during comprehensive orthodontic tooth movement 2)To correlate the rate of canine retraction with the concentrations of biomarkers in GCF (RANKL & OPG) following the injection of vitamin D3 & i-PRFTimepoint: 8 weeks	—

Countries

India

Contacts

Public ContactJITENDRA SHARAN

AIIMS BHUBANESWAR

dent_jitendra@aiimsbhubaneswar.edu.in9968856761

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026