Which drug is better for nebulization either ropovacaine or ketamine before intubation and after extubation

Comparison of the effect of nebulization with ropivacaine versus nebulization with ketamine on hemodynamic response and postoperative sore throat in patient undergoing surgery under general anaesthesia- a randomized controlled trial - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/100908

Enrollment

Registered

2026-01-12

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: PCS-

Interventions

Intervention1: Nebulization with ketamine group: 1mg/kg mixed with normal saline to make total volume of 5ml Control Intervention1: Nebulization with ropivacine: 0.75% ropivacaine , total volume of 5m

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and 2,single attempt of intubation within 15 seconds,elective surgery under 2hours of duration

Exclusion criteria

Exclusion criteria: Allergy to study drugs,respiratory disease,pregnancy and lactation,

Design outcomes

Primary

Measure	Time frame
Hemodynamic response after intubationTimepoint: Before nebulization,immediately after intubation,5 minutes after intubation,post extubation	—

Secondary

Measure	Time frame
Postoperative sore throatTimepoint: 5 minutes After extubation,6hours after extubation,	—

Countries

India

Contacts

Public ContactDr Monika Gupta

Dr S N Medical College, Jodhpur

moniks111@gmail.com9414377221

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026