A study to see how gum treatment affects inflammation levels in saliva (Interleukin-6, a marker of inflammation) in women with polycystic ovarian syndrome (PCOS) and gum disease

EFFECTS OF NON-SURGICAL PERIODONTAL THERAPY ON SALIVARY INTERLEUKIN-6 LEVELS IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME AND PERIODONTITIS: A RANDOMIZED CONTROLLED CLINICAL STUDY - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/100860

Enrollment

Registered

2026-01-12

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E282- Polycystic ovarian syndrome

Interventions

Intervention1: Periodontal therapy: One group of participants will be given non-surgical periodontal therapy which would include- Supragingival and subgingival scaling and root planing, crown polishin

Eligibility

Inclusion criteria

Inclusion criteria: 1- Systemically Healthy females of reproductive age (15 45 years) 2- Females diagnosed with PCOS 3- Females diagnosed with Periodontitis 4- At least 16 teeth present in oral cavity

Exclusion criteria

Exclusion criteria: 1- Patients with a history of Periodontal therapy for the last 6 months. 2- Chronic or acute infections during the previous 6 months. 3- Pregnant or lactating females 4- Systemic antibiotic treatment in the past 6 months. 5- Any other systemic disease that could influence the outcome of the periodontal therapy. 6- Regular use of nonsteroidal anti-inflammatory drugs or hormone replacement therapy.

Design outcomes

Primary

Measure	Time frame
Change in salivary Interleukin-6 levelsTimepoint: Baseline and 1 month	—

Secondary

Measure	Time frame
Change in clinical periodontal parameters- Plaque index, Gingival Index, Bleeding on probing, Probing Pocket Depth, Clinical attachment level.Timepoint: Baseline and 1 month	—

Countries

India

Contacts

Public ContactDr Anjani Kumar Pathak

dr.anjanipathak@gmail.com

dr.anjanipathak@gmail.com9415373505

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026