A Comparative Evaluation of Articaine and Lignocaine, Each Combined with Dexamethasone, in Impacted Mandibular Third Molar Surgery.

Comparative efficacy of 4 percent articaine with dexamethasone versus 2 percent lignocaine with dexamethasone in impacted third molar surgery - a triple blind randomized study - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/100814

Enrollment

Registered

2026-01-12

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M279- Disease of jaws, unspecified

Interventions

Intervention1: 2% lignocaine with 1:80,000 adrenaline 4% articaine with 1:100000 epinephrine: A single dose of local anaesthetic will be administered via inferior alveolar nerve block (intraoral route

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiologists (ASA) type I, A normal healthy patient. Patient with impacted mandibular third molars requiring surgical extraction under local anaesthesia. Patients with Pederson s difficulty index score 5-6 (moderately difficult)

Exclusion criteria

Exclusion criteria: Impacted third molar with associated pathology and acute infection. Patient who has a known allergy to a local anaesthetic or requiring repeated injections of local anaesthetics. Medically compromised patients. Tobacco chewers and smokers Pregnancy and lactating females or patients on oral contraceptives.

Design outcomes

Primary

Measure	Time frame
Latency period Duration of anaesthesia Post operative pain Visual analog scale of 0-10 Facial swelling a silk thread will be used to take three measurements from 4 facial reference points. Tragus Angle of mouth. Angle of mandible Outer canthus of eye. Angle of mandible Ala of nose. Angle of mandible Corner of mouth. Mouth opening (trismus) interincisal distance is measured using vernier calliperTimepoint: Post operative pain Visual analog scale of 0-10 postoperatively 1st, 3rd and 7th day Facial swelling a silk thread will be used to take three measurements from 4 facial reference points. Tragus Angle of mouth. Angle of mandible Outer canthus of eye. Angle of mandible Ala of nose. Angle of mandible Corner of mouth. on postoperatively 1st, 3rd and 7th day Mouth opening (trismus) interincisal distance is measured using vernier calliper on postoperatively 1st, 3rd and 7th day	—

Measure

Time frame

Latency period Duration of anaesthesia Post operative pain Visual analog scale of 0-10 Facial swelling a silk thread will be used to take three measurements from 4 facial reference points. Tragus Angle of mouth. Angle of mandible Outer canthus of eye. Angle of mandible Ala of nose. Angle of mandible Corner of mouth. Mouth opening (trismus) interincisal distance is measured using vernier calliperTimepoint: Post operative pain Visual analog scale of 0-10 postoperatively 1st, 3rd and 7th day Facial swelling a silk thread will be used to take three measurements from 4 facial reference points. Tragus Angle of mouth. Angle of mandible Outer canthus of eye. Angle of mandible Ala of nose. Angle of mandible Corner of mouth. on postoperatively 1st, 3rd and 7th day Mouth opening (trismus) interincisal distance is measured using vernier calliper on postoperatively 1st, 3rd and 7th day

—

Secondary

Measure	Time frame
Age, Gender Post operative pain on 7th dayTimepoint: Age, Gender Post operative pain using VAS (Visual Analog Scale)	—

Countries

India

Contacts

Public ContactDr Rajdeep Singh

Chhattisgarh Dental College and Research Institute

rajdeepsinghdurg@gmail.com7587101121

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026