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Comparative evaluation of healing outcomes using platelet rich fibrin with and without antibiotic coating in patients with intrabony periodontal defects

Comparative evaluation of efficacy of platelet rich fibrin versus metronidazole coated platelet rich fibrin in the treatment of intrabony periodontal defects A randomized controlled clinical trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/100786
Enrollment
18
Registered
2026-01-09
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Platelet Rich Fibrin: Autologous platelet rich fibrin prepared from the patient s venous blood using standard centrifugation protocol and placed into intrabony periodontal defects follo

Sponsors

Educare Institute Of Dental Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy male and female patients aged twenty five to sixty years presenting with at least two intrabony periodontal defects. Patients should have no contraindication to periodontal surgery and should provide written informed consent.

Exclusion criteria

Exclusion criteria: Patients with systemic diseases affecting wound healing. Pregnant or lactating women. Patients who received periodontal treatment in the last six months. Patients with smoking or tobacco habits. Patients with known allergy to metronidazole. Physically or mentally challenged patients.

Design outcomes

Primary

MeasureTime frame
Radiographic bone fill will be assessed using cone beam computed tomography at baseline and at 9 months postoperatively.Timepoint: 9 months

Secondary

MeasureTime frame
To evaluate the effect of antibiotic incorporated platelet rich fibrin in the treatment of intrabony defects. To assess the influence of platelet rich fibrin with and without antibiotic incorporation on the clinical parameters Plaque index (PI), Gingival index (GI), Clinical Attachment Loss (CAL), Probing pocket depth(PPD) and Wound healing index(WHI). To compare the effect of platelet rich fibrin with and without antibiotic incorporation in the bone fill of periodontal intra bony defect. Timepoint: 9 months

Countries

India

Contacts

Public ContactAnagha Anil

Department Of Periodontology And Oral Impalntology,Educare Institute Of Dental Sciences,Malappuram,Kerala,India

srk.puthalath@gmail.com9995693673

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026