Health Condition 1: M00-M99- Diseases of the musculoskeletal system and connective tissue
Conditions
Interventions
Intervention1: Methotrexate: Tab. Methotrexate (Starting dose 5 mg/week)
Intervention2: Tofacitinib: Tofacitinib 5mg/day BD
Control Intervention1: NIL: NIL
Control Intervention2: combination of Tofaci
Sponsors
Eras Lucknow Medical College Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Age 18 or more than 18 years both males and females. Diagnosis of rheumatoid arthritis according to the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR)[A score of greater than or equal to 6/10 confirms the diagnosis of Rheumatoid Arthritis].
Exclusion criteria
Exclusion criteria: Any chronic systemic disease of liver, kidney, lungs and gastrointestinal tract. Other joint diseases (e.g. Osteoarthritis, Gout, Ankylosing Spondylitis) Severely immuno-compromised patient. Pregnant or breastfeeding women. Patient having contraindication for methotrexate(e.g. chronic liver disease, Bone marrow suppression, Active infections, Severe renal impairment).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effectiveness of treatment evaluated by End Study Investigation and ACR20/ACR50/ACR70 response evaluation.Timepoint: 4 Wk 8 Wk 12 Wk 16 Wk 20 Wk and 24 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactSingh Shashikumar Jitendra
Eras Lucknow Medical college and hospital
Outcome results
None listed