Animal and clinical study is to find out whether Chakshushya Basti an Ayurvedic treatment is effective and safe in reducing dryness irritation and discomfort in people suffering from Dry Eye syndrome

Experimental and clinical study to evaluate the effect of Chakshushya Basti in Dry Eye syndrome - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/100686

Enrollment

Registered

2026-01-09

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H041- Other disorders of lacrimal gland

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Experimental Study 1. Healthy Murine model of either gender will be considered. 2. Weight- 150 to 250 g. Clinical Study 1.Subject between age group of 20-50 years 2.Subjects irrespective of sex and religion 3.Subjects fit for basti karma 4.Subjects having minimum three ocular symptoms of 5.Dry eye syndrome as per diagnostic criteria 6.Subjects who are ready to sign the consent form

Exclusion criteria

Exclusion criteria: Experimental Study 1. Weight less than 150g and greater than 250 g. 2. Pregnant and diseased murine model. 3. Murine model that are under trial of other experiments or previous experiment Clinical Study 1.Known cases of severe ophthalmic conditions like Steven Johnsons, Chemical Thermal Radiation burns, Idiopathic atrophy, Trachoma, Ocular pemphigoid. 2.Known cases of Neuroparalytic Keratitis, post-measles infection of cornea, Pterygium, Tumours, low grade bacterial/viral conjunctivitis 3.Any condition which jeo paradise the study 4.Known cases of Systemic disorder and autoimmune disorder 5.Diagnosed cases of inflammatory and infective ocular conditions

Design outcomes

Primary

Measure	Time frame
Improvement in Tear Film Stability assessed by Tear Break-Up Time (T-BUT) before and after intervention. 2. Increase in Tear Secretion evaluated by Schirmer s Test readings. 3. Histopathological improvement in corneal epithelial cell integrity and reduction in desquamation through Hematoxylin Eosin staining (experimental arm only) Timepoint: 1st assessment - Before Treatment (0th Day) 2nd assessment -end of Basti treatment (10th day) 3rd assessment- 30th day	—

Measure

Time frame

Improvement in Tear Film Stability assessed by Tear Break-Up Time (T-BUT) before and after intervention. 2. Increase in Tear Secretion evaluated by Schirmer s Test readings. 3. Histopathological improvement in corneal epithelial cell integrity and reduction in desquamation through Hematoxylin Eosin staining (experimental arm only) Timepoint: 1st assessment - Before Treatment (0th Day) 2nd assessment -end of Basti treatment (10th day) 3rd assessment- 30th day

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Secondary

Measure	Time frame
1 Reduction in subjective symptoms such as dryness itching burning foreign body sensation eye strain assessed by OSDI (Ocular Surface Disease Index) questionnaire Dry Eye Grading Severity Scheme 2 Improvement in Visual Acuity 3 Observation of Samyak Niruha Basti Lakshana 4 Assessment of safety tolerance by monitoring any Adverse Drug Reactions (ADR)Timepoint: 1st assessment Before Treatment (0th Day) 2nd assessment By end of Basti treatment (10th day) 3rd assessment by 30th day	—

Measure

Time frame

1 Reduction in subjective symptoms such as dryness itching burning foreign body sensation eye strain assessed by OSDI (Ocular Surface Disease Index) questionnaire Dry Eye Grading Severity Scheme 2 Improvement in Visual Acuity 3 Observation of Samyak Niruha Basti Lakshana 4 Assessment of safety tolerance by monitoring any Adverse Drug Reactions (ADR)Timepoint: 1st assessment Before Treatment (0th Day) 2nd assessment By end of Basti treatment (10th day) 3rd assessment by 30th day

—

Countries

India

Contacts

Public ContactDr Prapulla K

Sri Dharmasthala Manjunatheshwara college of Ayurveda and hospital, hassan

drlohithba@sdmcahhassan.org9886749168

Outcome results