Health Condition 1: G908- Other disorders of autonomic nervous system
Conditions
Interventions
Intervention1: Low dose local anaesthetic block: Six injections will be given once a week. The intervention will be delivered to the vagus nerve and stellate ganglion depending on the clinical present
Sponsors
Amrita Institute of Medical sciences
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria were Hypoxic Ischemic Encephalopathy within the first three months, not on a ventilator or inotropic support, CRS-R 3 to 8, radiological grading stage 38, storming by PSH criteria 9, PSH not resolving a week from coming out of ICU, DLT score of 5+, propranolol at maximum tolerate doses, minimal acute phase reactant elevation and culture negative.
Exclusion criteria
Exclusion criteria: Exclusion criteria were requiring celiac ganglion block,sepsis concomitant UTI, upper GI bleed confirmed by occult blood testing, and comorbid Psychiatric Orthopedic, or Neurological conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| reduced PSH scoreTimepoint: 0,1,2,3,4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| estimate the change in PSH and DTC and evaluate the toxicities and adverse events associated with delivering multiple doses of low dose local anesthetic.Timepoint: 0,1,2,3,4 weeks | — |
Countries
India
Contacts
Public ContactDr Ravi Sankaran
Amrita Hospitals
Outcome results
None listed