Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Alendronate Solution: Dose- 0.2 ml
Concentration- 75 mg Alendronate in 100 ml Distilled water
Frequency- once applied during implant placement.
Route of administration- applied locally
Sponsors
Dr Raghvendra Gupta
Eligibility
Inclusion criteria
Inclusion criteria: Bilateral nearly symmetrical edentulous site, Two Edentulous site with at least one natural tooth in between, Sufficient alveolar bone at the site, Systemically healthy patients, No acute infection.
Exclusion criteria
Exclusion criteria: Medically compromised patients, Poor bone quality or volume, Para functional habits, Habit of smoking, alcohol intake or drug abuse, Pregnant woman and lactating mother.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intra oral periapical radiograph (IOPAR) /Cone beam computed tomography (CBCT) will be taken to assess the crestal bone level (from platform of implant till bone level, first implant bone interface)Timepoint: (1) Baseline- On the day of surgery immediately after implant placement (2) At implant loading, 4 to 6 months from implant placement (3) After 3 months from implant loading | — |
Secondary
| Measure | Time frame |
|---|---|
| Plaque Index (PI)Timepoint: These clinical parameters will be collected pre and post operatively- (1) Baseline- On the day of surgery before implant placement (2) At implant loading, after 4-6 month from implant placement (3) After 3 months from implant loading.;Gingival Index (GI)Timepoint: These clinical parameters will be collected pre and post operatively- (1) Baseline- On the day of surgery before implant placement (2) At implant loading, after 4-6 month from implant placement (3) After 3 months from implant loading.;Peri- Implant Probing Pocket Depth (PIPPD) - This assessment will be done post operatively at 4 sites around implant (Mesio- Buccal, Buccal, Disto- Buccal, Palatal)Timepoint: (1) Baseline- At implant loading, after 4-6 month from implant placement (2) After 3 months from implant loading.;Implant Stability - This assessment will be Resonance Frequency Analysis (RFA) done intra and post operatively using Osstell device in Implant Stability Quotient (ISQ) valueTimepoint: (1) Baseline- On the day of surgery immediately after implant placement (2) At implant loading, after 4 to 6 months from implant placement (3) After 3 months from implant loading.;Peri-Implant Crevicular Fluid (PICF) sample collected by Periopaper strips and analyzed for Cathepsin K (CatK) and Osteocalcin (OC) levels using Enzyme- Linked Immunosorbent Assay (ELISA).Timepoint: These assessment will be done post operatively- (1) After 2 weeks from implant placement (2) After 4 weeks from implant placement (3) After 4 to 6 months from implant placement, at the time of implant loading (4) After 3 months from implant loading. | — |
Countries
India
Contacts
Public ContactDr Raghvendra Gupta
Faculty of Dental Sciences, Uttar Pradesh University of Medical Sciences
Outcome results
None listed