Comparing efficacy of two medications, Magnesium Sulphate versus Lidocaine Nebulization for Preventing Sore Throat in Patients undergoing surgeries under General Anaesthesia

Comparative Evaluation of post operative sore throat after nebulization with magnesium sulphate versus lidocaine in patients undergoing general anaesthesia. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/100599

Enrollment

Registered

2026-01-08

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: inj Magnesium sulphate: preoperative Nebulization with Magnesium Sulphate (500mg) [1ml of MgSO4 diluted in 4ml of Normal Saline(NS)] Control Intervention1: inj Lignocaine 2%: preoperati

Eligibility

Inclusion criteria

Inclusion criteria: 1- American Society of Anaesthesiology (ASA) grade I and II 2- Hemodynamically stable patients with all routine investigations within the normal limits. 3- Patients who give informed written consent and are willing to be a part of the study.

Exclusion criteria

Exclusion criteria: 1. Patient refusal to be a part of the study 2. History of allergy to the drug being used in the study 3. Patients with severe cardiovascular or respiratory disorders 4. Patients with difficult airway or requiring nasal intubation 5. Patients on steroid therapy 6. Subjects who cough or bucked before extubation 7. Surgeries involving oral cavity, airway, head and neck surgeries

Design outcomes

Primary

Measure	Time frame
To compare the incidence of post operative sore throat after nebulization with magnesium sulphate versus lidocaine in patients undergoing general anaesthesia requiring endotracheal intubation Timepoint: Incidence of sore-throat in both groups at 0, 2, 4, 6, 12, 24 hours post-surgery	—

Secondary

Measure	Time frame
1. To assess effect of nebulisation with magnesium sulphate and lidocaine on haemodynamic parameters 2. To assess post operative sedation 3. Overall patient comfort post-surgery 4. Any drug related side effects. Timepoint: 1. Haemodynamic parameters - HR, SBP, DBP, MAP and SpO2 will be observed- A. just prior to administering nebulisation B. at the time of induction of GA C. at the time of extubation 2. Post operative sedation as per Ramsay sedation score 3. Any postoperative side effect or complications	—

Measure

Time frame

1. To assess effect of nebulisation with magnesium sulphate and lidocaine on haemodynamic parameters 2. To assess post operative sedation 3. Overall patient comfort post-surgery 4. Any drug related side effects. Timepoint: 1. Haemodynamic parameters - HR, SBP, DBP, MAP and SpO2 will be observed- A. just prior to administering nebulisation B. at the time of induction of GA C. at the time of extubation 2. Post operative sedation as per Ramsay sedation score 3. Any postoperative side effect or complications

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Countries

India

Contacts

Public ContactDr Bhavini Shah

Department of Anaesthesiology, Dr. D.Y. Patil Medical College, Hospital and Research Centre

drbhavinishah71@gmail.com9850829994

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026