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Effect of genicular nerve alcohol neurolysis on quality of life in patients with severe osteoarthritis knee

Effect of genicular nerve alcohol neurolysis on quality of life in patients with severe knee osteoarthritis: A prospective study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/100580
Enrollment
30
Registered
2026-01-08
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: Genicular Nerve Alcohol Neurolysis: Ultrasound guided genicular nerve alcohol neurolysis of the superomedial, superolateral and inferomedial genicular nerves. Diagnostic block is perfor

Sponsors

Dr Pinku Kumawat
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients aged above 40 years 2 Chronic knee pain for at least 6 months unresponsive to conservative treatment 3 Radiologically confirmed severe knee osteoarthritis Kellgren Lawrence Grade 3 or 4 4 Ability and willingness to provide informed consent and comply with study procedures

Exclusion criteria

Exclusion criteria: 1 KL Grade 1 or 2 2 Diabetes mellitus hepatic renal or psychiatric illness 3 Patients on immunosuppressive drugs 4 Collagen vascular disorders 5 Cancer or malignant disorders 6 Local infection at knee 7 Autoimmune or platelet disorders 8 Use of anticoagulant or antiplatelet therapy within 10 days prior to procedure 9 Intra-articular injection to knee within last 3 months 10 Genu valgum or varum greater than 20 degrees 11 HIV, HBV, HCV or VDRL positive status 12 Knee surgery on affected side within previous 12 months 13 Inflammatory or systemic knee disease 14 High likelihood of loss to follow-up 15 History of trauma to the affected knee

Design outcomes

Primary

MeasureTime frame
Change in pain severity measured using WOMAC scoreTimepoint: Baseline, 2 weeks, 6 weeks and 3 months after intervention—

Secondary

MeasureTime frame
Change in pain intensity measured using Numeric Rating Scale (NRS)Timepoint: Baseline, 2 weeks, 6 weeks and 3 months;Change in quality of life measured using SF-12 scoreTimepoint: Baseline and 3 months;Adverse events following genicular nerve alcohol neurolysis (swelling, numbness, paraesthesia, motor weakness, or any other)Timepoint: Assessed at 2 hours post-procedure, 2 weeks, 6 weeks and 3 months—

Countries

India

Contacts

Public ContactDr Deepak Kumar Garg

JLN Medical College, Ajmer

drdeepakgarg04@gmail.com9829399322

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026