Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Dextrose Prolotherapy: Participants will be positioned supine with the target knee flexed 10 15 and prepared under strict aseptic precautions using povidone-iodine and alcohol.Ultrasou
Sponsors
Nil Ratan Sircar Medical College and Hospital Kolkata
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with primary knee osteoarthritis fulfulling ACR criteria. 2.Radiologically confirmed Kellgren Lawrence Grade II knee Osteoarthritis. 3.VAS pain score more than or equal to 6 in past 2 weeks. 4.Willing and able to provide informed consent and comply with study follow up.
Exclusion criteria
Exclusion criteria: 1.Intra-articular injection in any joint within the past 6 months. 2.Use of NSAIDs, analgesics, or slow-acting OA drugs within the restricted time frame. 3.History of knee surgery or arthroscopic procedure in the last 1 year. 4.Secondary or inflammatory arthritis, generalized OA, or coexisting hip/foot OA or back pain. 5.Ligament or meniscal injury, tense effusion, or cutaneous lesions over the knee. 6.BMI more than 35 7.Haemoglobin less than 10 g/dL. 8.Bleeding disorders, or anticoagulant therapy. 9.Presence of active infection, immunosuppression, neoplasm, or systemic illness (e.g., uncontrolled diabetes, thyroid disease). 10.Presence of nociplastic pain
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain reduction measured by Visual Analogue Scale (VAS)Timepoint: Baeline 4 weeks 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional outcome assessed by KOOS (Knee injury and Osteoarthritis Outcome Score). Duration of effect. Adverse events,if any. Timepoint: Baseline 4 weeks 12 weeks | — |
Countries
India
Contacts
Public ContactPartha Pratim Das
NRS Medical College
Outcome results
None listed