Health Condition 1: M059- Rheumatoid arthritis with rheumatoid factor, unspecified
Conditions
Interventions
Intervention1: Tailored exercise regimen: Exercise regimen including a supervised strength training module, aerobic exercise and flexibility
Control Intervention1: Nil: NOT APPLICABLE
Sponsors
Central Research and Publication Unit
Eligibility
Inclusion criteria
Inclusion criteria: Patients of diagnosed RA ACR-EULAR 2010 Criteria Sarcopenia as per AWGS criteria
Exclusion criteria
Exclusion criteria: 1.Diagnosed cases of end stage chronic kidney disease , decompensated chronic liver disease, Heart failure, infections, COPD, interstitial lung disease with functional impairment, permanent neurological disorders, cancers, or on medication for these 2. ACR functional status class IV : Limited ability to perform usual self-care, work, and hobbies. 3. Overlap with other connective tissue disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the efficacy of a tailored exercise regimen on the muscle mass, fat mass, sarcopenia and sarcopenic obesity as assessed by Bioelectrical impedance analysis (BIA) and clinical measures in sarcopenic patients of rheumatoid arthritisTimepoint: 4 weeks, 8 weeks, 12 weeks, 16 weeks and 24 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| To estimate levels of the myokine myostatin and exerkine irisin in this population pre and post intervention To determine the duration needed to achieve a change in the severity of sarcopenia To determine disease activity (DAS 28-CRP), fatigue (FACIT-F), disability (HAQ-DI), quality of life (EQ5D5L) pre and post the intervention To determine the associations between sarcopenia/sarcopenic obesity, disease parameters and myokine levels Timepoint: 4 weekly muscle mass assessment final time point-24 weeks | — |
Countries
India
Contacts
Public ContactDr Varsha Bhatt
Bharati Vidyapeeth (Deemed to Be) University Medical College and Hospital ,Pune
Outcome results
None listed