Health Condition 1: F05- Delirium due to known physiological condition
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Syrup Melatonin 3mg: Prophylactic melatonin syrup for prevention of delirium in critical care for 14 days
Sponsors
MEDICAL COLLEGE AND HOSPITALKOLKATA
Eligibility
Inclusion criteria
Inclusion criteria: Adults ( more than 18 years). Expected ICU stay more than 48 hours. Informed consent obtained from patient or legal guardian.
Exclusion criteria
Exclusion criteria: ICU admission more than 48 hours at the time of screening. Unable to assess for delirium (eg, coma or deep sedation; receiving neuromuscular blocking drugs) at the time of screening. History of severe cognitive or neurodegenerative disease (eg, dementia, Parkinson s disease) or severe structural brain injury (eg, traumatic brain injury, intracranial haemorrhage. Severe hepatic or renal dysfunction. Known allergy to melatonin. Absolute contradiction to enteral nutrition (eg, gastrointestinal obstruction,perforation,recent gastrointestinal surgery,deemed strict nil by mouth,lack of enteral access). Pregnant and lactating women. Active seizures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of deliriumTimepoint: 14 Days | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of Delirium, Time to Onset of Delirium, Length of ICU Stay, Sedation Requirements, Sleep Quality, ICU mortalityTimepoint: 14 Days | — |
Countries
India
Contacts
Public ContactAdhishree K
MEDICAL COLLEGE AND HOSPITAL,KOLKATA
Outcome results
None listed