Effects of Micro-Osteoperforations Following Placement of Blood Concentrates on the Rate of Maxillary Canine Retraction and the Expression of Various Biomarkers in Gingival Crevicular Fluid During Comprehensive Orthodontic Treatment

Effects of Mini-Screw Implant Assisted Micro-Osteoperforations Following Placement of Autologous Leukocyte-Platelet-Rich Fibrin on the Rate of Maxillary Canine Retraction and the Expression of Various Biomarkers in Gingival Crevicular Fluid During Comprehensive Orthodontic Treatment: A Split-Mouth Randomized Clinical Trial - Nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/100512

Enrollment

Registered

2026-01-07

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M264- Malocclusion, unspecified

Interventions

Intervention1: Leukocyte-platelet-rich fibrin placement and micro-osteoperforation: Placement of leukocyte-platelet-rich fibrin plug in the extraction socket on the right and left of the dental arch,

Eligibility

Inclusion criteria

Inclusion criteria: 1)Subjects having Class I bimaxillary dentoalveolar protrusion malocclusion or Class II div 1 malocclusion with normodivergent growth pattern (FMA 20â??28), minimum spacing, or crowding (2â??5 mm) in maxillary and mandibular arches require either all 1st premolar extraction or only upper 1st premolar extraction for the correction of their malocclusion. 2)Presence of a full complement of teeth except for the third molar. 3)Good oral hygiene(gingival index score less than 1, probing depth less than 3mm)

Exclusion criteria

Exclusion criteria: 1)History of complete or incomplete comprehensive orthodontic treatment 2)Subject who fails to maintain proper oral hygiene all through the orthodontic treatment 3)Subjects with pregnancy 4)Subjects with any known syndrome 5)Subjects with any calcium and phosphate metabolism affecting disorder 6)Subjects on long-term medication like NSAIDs or steroids 7)Lack of manual dexterity 8)Any medications for a systemic illness 9)History of recent bacterial or viral infection 10)Known blood disorders like thrombocytopenia, leukopenia, etc.

Design outcomes

Primary

Measure	Time frame
To evaluate the effects of micro osteoperforation following placement of L-PRF plug on the rate of canine retraction during comprehensive orthodontic treatment.Timepoint: T0- 0 DAY T1- 30TH DAY T2- 45TH DAY T3- 60TH DAY T4- 75TH DAY T5- 90TH DAY	—

Secondary

Measure	Time frame
1)To assess the effects of micro-osteoperforation following placement of L-PRF plug on the concentration of various biomarkers in the GCF during the comprehensive orthodontic treatment. 2)To correlate the concentration of biomarkers (OPG, RANKL) with the rate of canine retraction in patients who underwent micro-osteoperforation following placement of L-PRF plug.Timepoint: T0- 0 DAY T1- 30TH DAY T2- 45TH DAY T3- 60TH DAY T4- 75TH DAY T5- 90TH DAY	—

Measure

Time frame

1)To assess the effects of micro-osteoperforation following placement of L-PRF plug on the concentration of various biomarkers in the GCF during the comprehensive orthodontic treatment. 2)To correlate the concentration of biomarkers (OPG, RANKL) with the rate of canine retraction in patients who underwent micro-osteoperforation following placement of L-PRF plug.Timepoint: T0- 0 DAY T1- 30TH DAY T2- 45TH DAY T3- 60TH DAY T4- 75TH DAY T5- 90TH DAY

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Countries

India

Contacts

Public ContactJitendra Sharan

All India Institute of Medical Sciences, Bhubaneswar

dent_jitendra@aiimsbhubaneswar.edu.in9968856761

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026