A Comparative Study of Three Sugammadex Doses to undo vecuronium induced muscle relaxation during surgery

Comparison Of Three Doses Of Sugammadex For Reversal Of Neuromuscular Blockade Induced By Vecuronium - Nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/100505

Enrollment

Registered

2026-01-07

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K802- Calculus of gallbladder without cholecystitis Health Condition 2: S625- Fracture of thumb Health Condition 3: S520- Fracture of upper end of ulna Health Condition 4: K565- Intestinal adhesions [bands] withobstruction (postinfection) Health Condition 5: C711- Malignant neoplasm of frontal lobe Health Condition 6: K358- Other and unspecified acute appendicitis

Interventions

Intervention1: Suggamadex 1mg/kg I/V: single dose of suggamadex 1mg/kg will be given for reversal of neuromuscular blockade by vecuronium through intravenous route Intervention2: suggamadex 1.5mg/kg I

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I-II, scheduled for surgery under general anaesthesia with controlled ventilation and with an expected duration of at least 50 min.

Exclusion criteria

Exclusion criteria: 1. Known neuromuscular Disorders 2. Known allergy 3. Taking medication known to alter the effect of neuromuscular blocking agents.

Design outcomes

Primary

Measure	Time frame
Time taken to reach TOF ratio of 0.9 from a TOF ratio of 0.4 after giving sugammadex will be noted and patient extubated once following verbal commands.Timepoint: 18 months	—

Secondary

Measure	Time frame
any signs of reoccurrence of muscle weakness or other adverse eventsTimepoint: every 15 minutes after extubation till 1 hour;patients reaching TOF count more than 0.9Timepoint: 5 minutes	—

Countries

India

Contacts

Public ContactDr Mahesh Chandra

Vardhaman Mahavir Medical College And Safdarjung Hospital

maheshhchandra@yahoo.in7291061045

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026