Effect of Ozonated olive oil Application on Pain, Swelling, Mouth Opening, and Antibiotic Requirement After Wisdom Tooth Removal Surgery

Evaluation of efficacy of topical ozone therapy on post operative sequelae following surgical removal of impacted mandibular third molar-A randomized control trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/100490

Enrollment

Registered

2026-01-07

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Topical Ozone Therapy: Extraction socket treated with ozonated olive oil post operatively antibiotics not prescribed analgesics given only when necessary. Topical application of the ozo

Eligibility

Inclusion criteria

Inclusion criteria: Patients with ASA-I status with age group 16-45 years Patients with presence of impacted lower third molar indicated for extraction Patients with similar difficulty Index(Pederson difficulty index) Patients willing to take part in the study

Exclusion criteria

Exclusion criteria: Participants with a history of drug abuse and alcohol intoxication Patients with Immunocompromised status. Patients with comorbidities such as hypertension and diabetes Presence of any local infection Women on oral contraceptives or pregnant and nursing mothers

Design outcomes

Primary

Measure	Time frame
Topical ozone therapy is expected to reduce postoperative pain, facial swelling, and trismus following impacted mandibular third molar surgery, as evidenced by lower analgesic use and improved mouth opening during follow-up. It is also anticipated to decrease the need for postoperative antibiotics without increasing complications, thereby proving to be a safe and effective adjunct for improving postoperative recovery.Timepoint: Facial swelling, mouth opening and pain level will be evaluated and recoded pre-operatively(T0). Patients will be monitored for pain, mouth opening, wound healing, swelling and number of analgesics taken at specified time intervals of T1-24 hours , T2 48 hours , T3- 72 hours and T4- 7th postoperative day.	—

Measure

Time frame

Topical ozone therapy is expected to reduce postoperative pain, facial swelling, and trismus following impacted mandibular third molar surgery, as evidenced by lower analgesic use and improved mouth opening during follow-up. It is also anticipated to decrease the need for postoperative antibiotics without increasing complications, thereby proving to be a safe and effective adjunct for improving postoperative recovery.Timepoint: Facial swelling, mouth opening and pain level will be evaluated and recoded pre-operatively(T0). Patients will be monitored for pain, mouth opening, wound healing, swelling and number of analgesics taken at specified time intervals of T1-24 hours , T2 48 hours , T3- 72 hours and T4- 7th postoperative day.

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Secondary

Measure	Time frame
nilTimepoint: nil	—

Countries

India

Contacts

Public ContactDr Apoorva Mowar

Subharti Dental College and Hospital,Swami Vivekanand University

drmowarapoorva@gmail.com9719051006

Outcome results