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Effect of Adding Probiotics to Routine Dental Cleaning on Gum Health in Adults with Gum Disease(Periodontitis)

Efficacy of Probiotics as an Adjunct to Scaling and Root Planing in Periodontitis: A Randomized, Double-Blind, Placebo-Controlled Trial - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/100487
Enrollment
108
Registered
2026-01-07
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K054- Periodontosis

Interventions

Intervention1: L. reuteri UBLRu-87 Chewable tablets: Two chewable tablet daily one in the morning, one at bed time after brushing the teeth.for 12 weeks Intervention2: multi-strain probiotic blend con

Sponsors

Dr Mehdi Ali Mirza
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Three or more natural teeth required per quadrant, with third molar exclusion 2. Moderate to severe periodontitis with the PD more than or equal to 4mm

Exclusion criteria

Exclusion criteria: 1. individuals who are on any probiotic supplements for the past 3 months 2. individuals who has received antimicrobial/ periodontal therapies in last 3 months. 3. Those who receive oral hygiene treatment. 4. Patients with dental emergencies requiring antibiotic therapy such as pain, abscess, etc 5. Patients with history of systemic disease, smoking, allergy to lactose and fermented milk products 6. Pregnant and lactating females or those planning pregnancy during the treatment period.

Design outcomes

Primary

MeasureTime frame
Change in probing pocket depth (PPD)Timepoint: Day0, 28 and 84

Secondary

MeasureTime frame
Changes in gingival recession (REC), bleeding on probing (BOP), , Winkel tongue coating index (WTCI), plaque index (PI) improvement in clinical attachment level (CAL) and reduction in volatile sulfur compounds (bad breath).Timepoint: Day 0, 28 and 84 (Volatile sulfur compounds- on day 56 also)

Countries

India

Contacts

Public ContactDr Mehdi Ali Mirza

ESIC Medical College and Hospital

mehdialimirza@gmail.com9160368850

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026