Comparing how well a persons own blood product helps move upper teeth backwards using Loops.

Comparative evaluation of the effectiveness of autologous leucocyte platelet-rich fibrin (l-prf) on the rate of maxillary en-masse retraction using frictionless mechanics: a split-mouth randomized clinical trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/100446

Enrollment

Registered

2026-01-07

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M264- Malocclusion, unspecified Health Condition 2: K088- Other specified disorders of teethand supporting structures

Interventions

Intervention1: Maxillary en-masse retraction using l-prf: After explaining the study to the patient, an informed consent will be taken from the patient before starting study. Orthodontic treatment wil

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients between age of 18-35years. 2. Any malocclusion requiring maxillary 1st premolar extraction. 3. Group A anchorage

Exclusion criteria

Exclusion criteria: 1. Traumatic extractions 2. Long-term corticosteroid therapy or bisphosphonate and nonsteroidal anti-inflammatory drug use. 3. Presence of ankylosed tooth 4. Pregnancy 5. History of maxillofacial or plastic surgery. 6. Subjects with craniofacial syndromes. 7. Group B or C anchorage 8. Patients with vertical growth pattern 9. Periodontally compromised patients

Design outcomes

Primary

Measure	Time frame
To assess the effectiveness of leukocyte platelet-rich fibrin (l-prf) compared with conventional treatment on En-masse retraction using frictionless mechanics.Timepoint: (T0) At The time of Extraction (T1) 30 Days after Extraction (T2) 60 Days after Extraction (T3) 90 Days after Extraction (T4) 120 Days after Extraction (T5) 150 Days after Extraction	—

Secondary

Measure	Time frame
To assess rate of maxillary en masse retraction with L-PRF using frictionless mechanics.Timepoint: (T0) At the time of Extraction (T1) 30 Days after Extraction (T2) 60 Days after Extraction (T3) 90 Days after Extraction (T4) 120 Days after Extraction (T5) 150 Days after Extraction;To assess rate of maxillary en masse retraction without L-PRF using frictionless mechanics.Timepoint: (T0) At the time of Extraction (T1) 30 Days after Extraction (T2) 60 Days after Extraction (T3) 90 Days after Extraction (T4) 120 Days after Extraction (T5) 150 Days after Extraction;To compare the difference in the rate of maxillary en-masse retraction using Frictionless mechanics with & without L-PRFTimepoint: (T0) At the time of Extraction (T1) 30 Days after Extraction (T2) 60 Days after Extraction (T3) 90 Days after Extraction (T4) 120 Days after Extraction (T5) 150 Days after Extraction	—

Measure

Time frame

To assess rate of maxillary en masse retraction with L-PRF using frictionless mechanics.Timepoint: (T0) At the time of Extraction (T1) 30 Days after Extraction (T2) 60 Days after Extraction (T3) 90 Days after Extraction (T4) 120 Days after Extraction (T5) 150 Days after Extraction;To assess rate of maxillary en masse retraction without L-PRF using frictionless mechanics.Timepoint: (T0) At the time of Extraction (T1) 30 Days after Extraction (T2) 60 Days after Extraction (T3) 90 Days after Extraction (T4) 120 Days after Extraction (T5) 150 Days after Extraction;To compare the difference in the rate of maxillary en-masse retraction using Frictionless mechanics with & without L-PRFTimepoint: (T0) At the time of Extraction (T1) 30 Days after Extraction (T2) 60 Days after Extraction (T3) 90 Days after Extraction (T4) 120 Days after Extraction (T5) 150 Days after Extraction

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Countries

India

Contacts

Public ContactDr Pradeep Kawale

Yogita dental college and hospital

drchetan1@yahoo.co.in942113435

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026