Research to identify how much norepinephrine safely keeps blood pressure stable during spinal anaesthesia for c section deliveries

Double blind randomised clinical trial to determine the effective bolus dose of norepinephrine in preventing spinal hypotension during caesarean delivery - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/100438

Enrollment

130

Registered

2026-01-07

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Norepinephrine 0.10 g/kg bolus IV followed by infusion: Intravenous bolus of norepinephrine 0.10 g/kg (2 g/mL concentration in 10 mL 5% dextrose) administered immediately after intra

Eligibility

Inclusion criteria

Inclusion criteria: 1) Parturients undergoing elective/emergency caesarean birth under spinal anaesthesia. 2).Full term singleton gestation. 3).American Society of Anaesthesiology Physical Status score of II.

Exclusion criteria

Exclusion criteria: 1) History of hypertension or cardiovascular disease. 2) Severely impaired liver or kidney function. 3) Coagulation abnormalities. 4) Patients on anti platelet and anticoagulant agents. 5) Fetal abnormality. 6) History of epilepsy. 7) Patients who do not give consent.

Design outcomes

Primary

Measure	Time frame
Incidence of spinal hypotension, defined as systolic blood pressure decrease to 80% of baseline between initiation of intrathecal injection and delivery.Timepoint: From initiation of intrathecal bupivacaine injection until delivery of baby	—

Secondary

Measure	Time frame
Frequency of hypertension & severe spinal hypotension Rescue drug administered from the time of subarachnoid block to the delivery Frequency of bradycardia Incidence of maternal nausea or vomiting Duration of hypotensionTimepoint: From initiation of intrathecal bupivacaine injection till the uterine closure	—

Countries

India

Contacts

Public ContactDrBasavaraj Kallapur

KMCRI Hubli

Doc_basu@yahoo.co.in6364503729

Outcome results