Health Condition 1: C189- Malignant neoplasm of colon, unspecified
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Intervention3: Nil: Nil
Sponsors
kasturba Medical College
Eligibility
Inclusion criteria
Inclusion criteria: CASE: Inclusion criteria: All adult patients diagnosed with colon carcinoma , attending Department of Surgical Oncology ,Kasturba Medical College and are scheduled for elective surgery who are willing to give informed consent will be included as cases in study. Controls: Inclusion criteria: Ten consenting age- and sex-matched healthy individuals will be enrolled from Department of Biochemistry. This study group of normal subjects is needed for baseline pilot data collection.
Exclusion criteria
Exclusion criteria: exclusion criteria for case:Colon cancer patients with prior chemotherapy, radiotherapy, or targeted therapy will be excluded. control: Any participant with any chronic metabolic disorders, on drugs which significantly alter metabolism (OHAs, statins, antimetabolites), patients who have undergone surgery/ trauma, pregnant women will be excluded from study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolomic profiling of pre, intra and post-surgical serum profiles in colon cancer patients might help in understanding of tumor specific metabolic reprogramming and post resection metabolic adaptations. Untargeted GC-MS enables identification and fold changes of signature metabolites are characteristic of tumor metabolism. The normalization of these metabolites post-operatively may function as indicators of successful tumor excision, whereas their continued dysregulation could imply incomplete resection or emerging disease recurrence. This metabolic profiling might refine precision oncology through metabolically informed adjuvant therapy selection and monitoring for recurrence.Timepoint: 1-12 months sample collection 12-18 sample processing | — |
Secondary
| Measure | Time frame |
|---|---|
| nilTimepoint: nil | — |
Countries
India
Contacts
Public ContactNithin Kumar U
Kasturba Medical College
Outcome results
None listed