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Effectiveness of Nasal Treatments Versus Standard Care for Headache Following Spinal Anaesthesia

Hospital based prospective and double blind randomised control trial - Comparision of efficacy of sphenopalatine ganglion block with intra nasal 4% lignocaine v/s intra nasal dexmedetomidine v/s conservative treatment of post dural puncture headache in patients undergoing surgery under spinal anaesthesia - Nil

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/100399
Enrollment
90
Registered
2026-01-06
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 8- Other Procedures

Interventions

Intervention1: Intranasal 4% lignocaine: Topical intranasal local anaesthetic applied to the mucosa over the pterygopalatine fossa produces a transnasal SPG block that relieves PDPH pain by interrupti

Sponsors

GSVM MEDICAL COLLEGE KANPUR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients giving consent . Patients in ASA Grade 1,2,3 Pateints within 5 days of dural puncture Patients returning to OPD with symptoms of PDPH after discharge

Exclusion criteria

Exclusion criteria: Patients not giving consent Patients with chronic headache, tension headache, migraine, Cluster headache. Patients with known nasal septal deviation or abnormalities such as polyps, intranasal tumors Patients with a history of any disorders involving the nose such as sinusitis, rhinitis Patients with a history of allergy to study medications (Lignocaine or Dexmedetomidine or paracetamol ) Patients on analgesic or undergoing treatment for headache. Patients with a history of addiction i.e. alcohol abuse or substance abuse.

Design outcomes

Primary

MeasureTime frame
Primary outcome of the study is to assess the Efficacy of SPGB for the treatment of PDPH and conservative management assessed by reduction in pain scoreTimepoint: Outcomes wil be assessed at baseline 15mins 30mins 1 hour 2 hours 6hours 12 hours 24hours 48 hours 72hrs

Secondary

MeasureTime frame
Secondary outcome of the study is to assess the Efficiency of the Sphenopalatine block & conservative management by the assessment of onset & duration of analgesia, as well as the development of any side effects associated with block , total dose of rescue analgesia & hospital discharge & patient satisfaction.Timepoint: Outcomes will be assessed at Baseline 15mins 30mins 1 hour 2 hours 6 hours 12 hours 24 hours 48 hours 72 hours

Countries

India

Contacts

Public ContactShivangi sachan

Ganesh Shankar vidyarthi memorial medical college

anil_16021976@rediffmail.co.in9336107410

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026