Effect of Dexmedetomidine which is a group of drug commonly used in anesthesia practice,before the surgery through nebulisation route of administration in addition to standard treatment on visibility of surgical field and haemodynamic stability during the surgery

Effect of preoperative dexmedetomidine nebulisation as an adjunct to adrenaline nasal packing on surgical field quality and haemodynamic stability during transsphenoidal resection of pituitary adenoma: A prospective randomised double-blinded clinical study - Nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/100398

Enrollment

Registered

2026-01-06

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Nebulised dexmedetomidine as an premedication: Nebulised dexmedetomidine(1 microgram per kilogram of body weight) will be given as a premedication in addition to adrenaline nasal packin

Eligibility

Inclusion criteria

Inclusion criteria: Age: 18 to 65 years BMI up to 30 kg/m2 ASA Physical Status I, II. Scheduled for elective transsphenoidal pituitary surgery

Exclusion criteria

Exclusion criteria: GCS less than 12 and elevated ICP History of known dexmedetomidine allergy Patients with significant cardiovascular and respiratory disease Patients coming for emergency surgery, pregnant patients. Individuals with Cushing syndrome and Acromegaly

Design outcomes

Primary

Measure	Time frame
To assess the efficacy of nebulised dexmedetomidine on surgical field quality in patients undergoing transsphenoidal resection of pituitary adenoma using Formmer s surgical field score (scored by a single operating neurosurgeon at defined time points). Timepoint: To assess the efficacy of nebulised dexmedetomidine on surgical field quality in patients undergoing transsphenoidal resection of pituitary adenoma using Formmer s surgical field score (scored by a single operating neurosurgeon at defined time points).At the end of the surgery	—

Measure

Time frame

To assess the efficacy of nebulised dexmedetomidine on surgical field quality in patients undergoing transsphenoidal resection of pituitary adenoma using Formmer s surgical field score (scored by a single operating neurosurgeon at defined time points). Timepoint: To assess the efficacy of nebulised dexmedetomidine on surgical field quality in patients undergoing transsphenoidal resection of pituitary adenoma using Formmer s surgical field score (scored by a single operating neurosurgeon at defined time points).At the end of the surgery

—

Secondary

Measure	Time frame
To evaluate the efficacy of nebulised dexmedetomidine on haemodynamic response in patients undergoing transsphenoidal resection of pituitary adenoma Timepoint: baseline,post nebulisation,Anesthesia induction,Intubation,Pre endoscopic insertion,Endoscopic insertion,Pre Adrenaline pack,Adrenaline Pack,Mucosal resection,Sphenoid drilling,Extubation,1 hour post extubation	—

Countries

India

Contacts

Public ContactDr Muhammed Thoufeeq T

AIIMS RAIPUR

thoufeeqt1999@gmail.com8592014453

Outcome results