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A study of thinking and memory abilities in brothers and sisters of people with schizophrenia

Cognitive functioning as a potential endophenotype in unaffected biological siblings of individuals with schizophrenia: A neurocognitive assessment study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/01/100388
Enrollment
80
Registered
2026-01-06
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil

Sponsors

Rithwik S
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Biological sibling (first degree) of an individual diagnosed with Schizophrenia Minimum education 5th standard or equivalent No current Psychiatric illness

Exclusion criteria

Exclusion criteria: History of neurological illness or intellectual disability Substance use disorders in past 6 months Serious medical illness affecting cognition Use of cognition impairing medications

Design outcomes

Primary

MeasureTime frame
To compare cognitive functioning (measured by Montreal Cognitive Assessment, Trail Making Test A & B, and Digit Span Forward and Backward) between unaffected biological siblings of individuals with schizophrenia and age, sex, and education matched healthy controls.Timepoint: Single time point at baseline—

Secondary

MeasureTime frame
To identify specific cognitive domains (attention, working memory, processing speed, & executive function) that are significantly impaired in unaffected biological siblings of individuals with schizophrenia compared to healthy controls.Timepoint: Single time point at baseline—

Countries

India

Contacts

Public ContactRithwik S

Vinayaka Missions Kirupananda Variyar Medical College and Hospitals

lakshmidorai.b@gmail.com9488761016

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026