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Effect of Two Nebulized Drug Combinations on Heart Rate and Blood Pressure During Breathing Tube Placement

COMPARATIVE EVALUATION OF NEBULIZED ROPIVACAINE (0.75%) PLUS DEXMEDETOMIDINE VERSUS NEBULIZED LIGNOCAINE (2%) PLUS DEXMEDETOMIDINE ON HEMODYNAMIC RESPONSE ON INTUBATION IN PATIENTS UNDERGOING SURGERY UNDER GENERAL ANAESTHESIA, A PROSPECTIVE RANDOMISED DOUBLE BLINDED STUDY - NIL

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/100306
Enrollment
104
Registered
2026-01-05
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H60-H95- Diseases of the ear and mastoid process

Interventions

Intervention1: Nebulization with 0.75% ropivacaine (4ml) plus dexmedetomidine (1ml): The Group RD receives nebulization with 0.75% ropivacaine (4ml) plus dexmedetomidine (1ml) Total volume 5ml over 15

Sponsors

Department of Anaesthesiology, AIIMS Rishikesh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Adult patients more than 18 years 2.American society of anaesthesiologists physical status I and II 3.Patients scheduled for elective surgeries requiring endotracheal intubation under general anaesthesia 4.Patient willing to participate and provide informed written consent 5.BMI less than 30 6.Both male and female

Exclusion criteria

Exclusion criteria: 1.Patient refusal 2.Patients undergoing emergency surgery 3.Patients with American society of anaesthesiologists physical status class III and IV 4.Known allergy or hypersensitive reaction to given drugs 5.Patient with substance abuse or alcohol dependence 6.Pregnant and Nursing Women 7.History of difficult intubation 8.Intubation time more than 20 seconds or more than one attempt or modified Mallampatti score III and IV

Design outcomes

Primary

MeasureTime frame
To compare the Mean Arterial Pressure changes following laryngoscopy and endotracheal Intubation between the study groups.Timepoint: Mean Arterial Pressure and heart rate measurement at baseline, post intubation and extubation at 1,3,5,7,9 minutes

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactAjit Kumar

All India Institute of Medical Sciences, Rishikesh Rishikesh

ajit.anaes@aiimsrishikesh.edu.in9910789377

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026