Health Condition 1: I999- Unspecified disorder of circulatory system
Conditions
Interventions
Intervention1: METHYLENE BLUE: METHYLENE BLUE EFFECT ON NORAD DOSE
Intervention2: Methylene blue and Vasopressin: Intravenous Vasopressin 0.04 units/min
Intravenous Methylene Blue 1 mg/kg bolus over 3
Sponsors
Subharti Medical College
Eligibility
Inclusion criteria
Inclusion criteria: Patient admitted in ICU with shock and requires noradrenaline to maintain a mean arterial pressure (MAP) of greater than or equal to 65 mm Hg after appropriate fluid resuscitation.
Exclusion criteria
Exclusion criteria: relatives/patient refused to provide consent With unstable coronary artery syndrome, stroke chronic renal failure requiring dialysis, malignancy or irreversible illness with a high mortality risk, acute mesenteric ischemia, pregnancy known hypersensitivity to norepinephrine or Methylene Blue or Vasopressin Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CHANGE IN NORAD DOSE AFTER STARTING VASOPRESSIN AND METHYLENE BLUETimepoint: 0 hours, 6 hours, 12 hours, 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in Lactate Levels, Urine Output Sequential organ failure assessment (SOFA) score. CRP levels Timepoint: 0hr 6hr 12hr 24hr | — |
Countries
India
Contacts
Public ContactAkshita
Subharti medical college
Outcome results
None listed