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To study the effectiveness of intravenous magnesium sulphate and intravenous lidocaine for attenuation of a cardiovascular response to laryngoscopy and endotracheal intubation in patients undergoing elective surgery.

A randomized controlled study to compare the effect of intravenous magnesium sulphate versus intravenous lidocaine on the cardiovascular response of endotracheal intubation in surgeries under general anaesthesia in SMS Medical College Jaipur - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/100272
Enrollment
75
Registered
2026-01-05
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Injection Magnesium sulphate intravenously ( 30 mg per kg ): Patient will be administered Injection Magnesium sulphate intravenously ( 30 mg per kg) diluted in 10ml of 0.9 percent norma

Sponsors

Department of Anaesthesia, S.M.S Medical College Jaipur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for elective surgeries under general anaesthesia 2. Patients of either sex of age between 18 to 60 years and American Society of Anaesthesiologists (ASA) I and II. 3. Patients willing to give Informed and written consent.

Exclusion criteria

Exclusion criteria: 1.Patients with known allergies to magnesium or lignocaine. 2.Patients with anticipated difficult airway. 3. Patients on beta or Calcium channel blockers. 4. Hypertensive patients whose blood pressure more than 140 by 90 mmHg. 5. Hypotensive patients whose systolic blood pressure less than 90 mmHg. 6. Patients with hypothyroidism or hyperthyroidism.

Design outcomes

Primary

MeasureTime frame
To assess and compare the effect of intravenous magnesium sulphate and lidocaine on mean heart rate 2 minute after intubation.Timepoint: 2 minutes.—

Secondary

MeasureTime frame
1. To assess and compare the effect on Mean Systolic blood pressure (SBP) between the three groups. 2. To assess and compare the effect on Mean Dystolic blood pressure (DBP) between the three groups. 3. To assess and compare the effect on Mean Arterial pressure (MAP) between the three Timepoint: 2 minutes, 5 minutes, 7 minutes.—

Countries

India

Contacts

Public ContactDr Mudit Mewara

S.M.S Medical College Jaipur Rajasthan

anupamag213@gmail.com9414240245

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026