Evaluation of Methadone in Reducing Hemodynamic Stress Response During Laryngoscopy and Endotracheal Intubation: A Single Group Interventional Study

Evaluation of Methadone s Role in Attenuating Hemodynamic Stress Response During Laryngoscopy and Endotracheal Intubation: A Single Group Interventional Study - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/100220

Enrollment

Registered

2026-01-02

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: INJ Methadone 0.3 mg/kg: Inj Methadone 0.3 mg/kg will be given 8 minutes prior intubation and patient will be monitored for 10 minutes after intubation to see intubation stress response

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult patients Age 18-60 2. Patients with American Society of Anesthesiologists(ASA) physical status class 1 or 2 3. Gender-both male and female 4. Patient willing to participate 5. BMI less than 30 6. Modified Mallampati Score I & II

Exclusion criteria

Exclusion criteria: 1. Patients refusal 2. patients undergoing emergency surgery 3. patients with American society of anesthesiologists(ASA) physical status class III & IV 4. Known allergy or hypersensitive reaction to Methadone 5. contraindications to Methadone 6. significant renal or liver dysfunction 7. preoperative opioid dependence or chronic opioid use 8. Pregnant and Nursing Women. 9. History of difficult intubation, Intubation time more than 20 seconds or more than one attempt or modified Mallampati score III & IV.

Design outcomes

Primary

Measure	Time frame
To evaluate the efficacy of methadone in reducing sympathoadrenal response during laryngoscopy and endotracheal intubation in adult patients undergoing general anesthesiaTimepoint: T0- baseline T1- pre induction T2-Pre intubation T3- 1 min after intubation T4 -3 min after intubation T5- 5 min after intubation T6- 7 min after intubation T7- 10 min after intubation	—

Secondary

Measure	Time frame
To evaluate the efficacy of methadone in reducing acute postoperative pain score measured by NRS scaleTimepoint: from time of extubation to 24 hours post operative period;To identify any potential adverse effects associated with intravenous methadone use within 24 hours postoperativelyTimepoint: within 24 hours post operative period	—

Countries

India

Contacts

Public ContactDr Ajit Kumar

All India Institute of Medical sciences Rishikesh

ajit.anaes@aiimsrishikesh.edu.in9910789377

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026