To compare effects of inducing drugs, etomiodate and propofol with noradrenaline on heart rate and blood pressure in adult heart disease surgical patients

Hemodynamic profiles of etomidate versus propofol-noradrenaline combination for induction of anaesthesia in adult cardiac surgical patients :A prospective observational cohort study - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/100201

Enrollment

100

Registered

2026-01-02

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I39- Endocarditis and heart valve disorders in diseases classified elsewhere

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Effects of intravenous propofol with nor-adrenaline (PN) on the hemodynamic profiles in cardiac surgical patients: Group PN will be recei

Eligibility

Inclusion criteria

Inclusion criteria: -ASA physical status III-IV - Patients able to comprehend and willing to participate. -Patients scheduled for elective cardiac surgeries (mitral /aortic/double valve surgery and/or coronary artery bypass grafting)

Exclusion criteria

Exclusion criteria: Patients refusal to participate Emergent of redo surgeries Difficult airway Morbid obesity Protocol violation

Design outcomes

Primary

Measure	Time frame
The primary outcome of this study will to measure the incidence of hypotension (fall in MAP more than 20% from the baseline value) during the first ten minutes following anaesthesia induction with etomidate versus propofol- norepinephrine combination.Timepoint: Hemodynamic parameters (MAP, SBP, DBP, and HR) will recorded at 21 time points baseline and every 30 seconds for 10 minutes after the induction agent will last injected.	—

Measure

Time frame

The primary outcome of this study will to measure the incidence of hypotension (fall in MAP more than 20% from the baseline value) during the first ten minutes following anaesthesia induction with etomidate versus propofol- norepinephrine combination.Timepoint: Hemodynamic parameters (MAP, SBP, DBP, and HR) will recorded at 21 time points baseline and every 30 seconds for 10 minutes after the induction agent will last injected.

—

Secondary

Measure	Time frame
The secondary outcome will to measure the number of time points where there will tachycardia and hypertension (heart rate and MAP rise more than 20% from the baseline value) to direct laryngoscopy and intubation in both groups or any adverse side effects seen.Timepoint: Number of time point ( measured every 30 sec) with tachycardia /hypertension to direct laryngoscopy	—

Countries

India

Contacts

Public ContactDR ALOK KUMAR BHARTI

Government

alok.bharti48@gmail.com09307645596

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026