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Patients with gum disease receiving nanoparticle infused gel and lycopene gel along with teeth cleaning procedure and its effect on salivary cortisol levels and gum disease parameters.

Comparative evaluation of effectiveness of nanoparticle infused gel and lycopene gel as an adjunct to scaling and root planing on salivary cortisol levels at different time interval in stage-III periodontitis- a clinico-biochemical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/100199
Enrollment
90
Registered
2026-01-02
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with stage III periodontitis 2. Site selected having probing pocket depth of more than or equal to 6mm and Clinical attachment level of more than or equal to 5mm. 3. Age group 25 to 65 years.

Exclusion criteria

Exclusion criteria: 1. Patients with medical disorders such as cardiovascular or renal disease, poorly controlled diabetes, liver diseases, malignancy, and radiotherapy. 2. Patients with recent history or presence of acute or chronic infection. 3. Pregnant women or lactating mothers. 4. Inability of the persons to co-operate because of their physical or mental status or daily routine. 5. Patients who has gone under any antibiotic therapy in previous 6 months.

Design outcomes

Primary

MeasureTime frame
1. To evaluate an effectiveness of gold and silver nanoparticles infused gel on salivary cortisol levels. 2. To evaluate an effectiveness of lycopene gel on salivary cortisol levels. 3. To evaluate an effectiveness of SRP alone on salivary cortisol levels. 4. To compare effectiveness of gold and silver nanoparticles infused gel, lycopene gel and SRP alone on salivary cortisol levelTimepoint: At baseline, 3 months and 6 months—

Secondary

MeasureTime frame
1. To evaluate an effectiveness of gold & silver nanoparticles infused gel on Plaque Index, Gingival Index, Probing Pocket Depth & Clinical Attachment Levels. 2. To evaluate an effectiveness of lycopene gel on Plaque Index, Gingival Index, Probing Pocket Depth & Clinical Attachment Levels. 3. To evaluate an effectiveness of SRP alone on Plaque Index, Gingival Index, Probing Pocket Depth & Clinical Attachment Levels. 4. To compare effectiveness of gold & silver nanoparticles infused gel, lycopene gel and SRP alone on Plaque Index, Gingival Index, Probing Pocket Depth & Clinical Attachment Levels.Timepoint: At baseline, 3 months & 6 months—

Countries

India

Contacts

Public ContactDr Sanjana Jirafe

PhD guide

drmbphadnaik@gmail.com9422254404

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026