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A Study utilising Radiotherapy of a higher dose of 74 Gray, involving patients of High Grade Brain tumours who have undergone surgery for the same, to see the Effects and Response of the Tumours to High Dose Radiotherapy.

A Pilot Study to evaluate Failure Patterns after Escalated Dose Radiotherapy to 74 Gy in High Grade Glioma (HGG): A Prospective Study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/100163
Enrollment
30
Registered
2026-01-01
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C719- Malignant neoplasm of brain, unspecified

Interventions

Intervention1: Cranial Radiation Therapy: Cranial Radiation Therapy delivered by Volumetric Modulated Arc Therapy (VMAT) to a dose of 74 Gray in 37 fractions Control Intervention1: Not Applicable: Not

Sponsors

Department of Radiotherapy and Clinical Oncology, PGIMER, Chandigarh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Histologically confirmed post operative cases of High Grade Gliomas including Astrocytoma Grade 3 or Grade 4, Glioblastoma Grade 4. Age greater than or equal to 18 years. KPS greater than or equal to 70. Adequate renal, hepatic and hematologic function. Patients willing to participate in the study with written and informed consent.

Exclusion criteria

Exclusion criteria: Pregnancy. Previous history of chemoradiation. Other primary, recurrent or metastatic disease. Patients with significant life-threatening co-morbidities. History of acute or chronic liver disease.

Design outcomes

Primary

MeasureTime frame
Failure Patterns.Timepoint: 3 months, 6 months, 9 months.—

Secondary

MeasureTime frame
Response Rate as per RANO criteria.Timepoint: 3 months, 6 months, 9 months.;Overall Survival and Progression free Survival.Timepoint: 9 months.;Quality of Life evaluation.Timepoint: 3 months, 6 months, 9 months.;Radiotherapy induced Radionecrosis.Timepoint: 6 months.;Impact of delayed T1 contrast enhance MRI on GTV.Timepoint:—

Countries

India

Contacts

Public ContactDr Narendra Kumar

Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh

drnarendra74@gmail.com7087009393

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026