Comparison of the effects of 3 types of platelet-based blood products in patients having Delayed union of fractures

COMPARATIVE ANALYSIS OF LR-PRP (Leucocyte Rich PRP) vs LP-PRP (Leucocyte Poor PRP) vs iPRF (injectable Platelet Rich Fibrin) IN DELAYED UNION OF FRACTURES - UNICENTRIC PROSPECTIVE RANDOMISED CONTROLLED TRIAL - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/01/100156

Enrollment

150

Registered

2026-01-01

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: LR-PRP: Leucocyte Rich Platelet Rich Plasma Intervention2: LP-PRP: Leucocyte Poor Platelet Rich Plasma Intervention3: iPRF: injectable Platelet Rich Fibrin Control Intervention1: NIL: N

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients in the age group 18 to 80 years of age 2) Patients with closed fractures coming to Dept. of Orthopaedics 3) Patients for whom delayed union has been proven by definition

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
To compare the functional outcomes of LR-PRP (Leucocyte Rich PRP) vs LP-PRP (Leucocyte Poor PRP) vs iPRF (injectable Platelet Rich Fibrin) in delayed union of fracturesTimepoint: Monthly once or twice	—

Secondary

Measure	Time frame
1. To promulgate a comprehensive definition and diagnosis criteria for Delayed union 2. To evaluate the functional outcomes of LR-PRP (Leucocyte Rich PRP) vs LP-PRP (Leucocyte Poor PRP) vs iPRF (injectable Platelet Rich Fibrin) in delayed union of fractures and Statistically Analyse the differencesTimepoint: Monthly once or twice	—

Countries

India

Contacts

Public ContactMadhan Jeyaraman

Sri Lalithambigai Medical College and Hospital

madhanjeyaraman@gmail.com8310600785

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026