Health Condition 1: J189- Pneumonia, unspecified organism
Conditions
Interventions
Intervention1: Hydrocortisone: Injection Hydrocortisone 100 mg TDS for 5 days then ,100 mg BD for 3 days , 100 mg OD for 2 days given to severe Pnumonia patients
Control Intervention1: standard of ca
Sponsors
DR Ashish Ranjan Sahoo and DR Srikant Behera
Eligibility
Inclusion criteria
Inclusion criteria: 1.Diagnosis of severe pneumonia as per ATS/IDSA guideline 2.consent to participate in study
Exclusion criteria
Exclusion criteria: 1 Patient was already on vasopressor therapy for septic shock at the time of inclusion 2 Diagnosed case of active tb herpes infection 3 History of preexisting structural lung disease on steroid dependent conditions 4 Hypersensitivity to corticosteroid 5 Known case of myelosuppression
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome To compare mortality of severe pneumonia patients on standard of care alone vs Hydrocortisone treatment along with standard of care at day 28 Timepoint: 28 day | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare duration of mechanical ventilation among standard of care alone vs Hydrocortisone along with standard of care groups Timepoint: 28 day;To compare ICU and Hospital LOS standard of care alone vs hydrocortisone along with standard of care groups Timepoint: 28 days;To compare adverse effects of Hydrocortisone Timepoint: 10 days | — |
Countries
India
Contacts
Public ContactDR Ashish Ranjan Sahoo
AIIMS Bhubaneswar
Outcome results
None listed