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Study to assess the effectiveness of an antibiotic antiseptic hydrogel wound dressing in preventing surgical site infection in patients undergoing orthopedic surgery.

Development of a Cefoperazone Sodium Incorporated with Chlorhexidine and Hydrogel Gauze for open and postoperative surgery wound dressing in Orthopaedic patients as Prophylactic and Therapeutic for Surgical Site Infections - N/A

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/100029
Enrollment
40
Registered
2026-01-01
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: T889- Complication of surgical and medical care, unspecified Health Condition 2: T814- Infection following a procedure Health Condition 3: T819- Unspecified complication of procedure

Interventions

Intervention1: Cefoperazone Sodium + Chlorhexidine Hydrogel Gauze Dressing: A locally developed hydrogel-based sterile gauze dressing impregnated with Cefoperazone Sodium (broad-spectrum cephalosporin

Sponsors

Dr Somesh Aravindan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: No Known Allergies to Cefoperazone or Chlorhexidine. Patients with open wounds or postoperative wounds. Patients with clean or clean-contaminated surgical wounds.

Exclusion criteria

Exclusion criteria: Patients with chronic non-healing wounds (e.g., diabetic ulcers, pressure sores). Severe immunocompromised conditions (e.g., uncontrolled diabetes, HIV). History of severe drug allergies or hypersensitivity reactions to antibiotics or antiseptics. Patients with active systemic infections requiring intravenous antibiotics.

Design outcomes

Primary

MeasureTime frame
Occurrence of surgical site infection within 30 days post-surgery, defined according to Centers for Disease Control and Prevention (CDC) criteria, including superficial incisional, deep incisional, and organ/space SSI.Timepoint: 30 days—

Secondary

MeasureTime frame
Number of days from surgery/wound dressing initiation to complete wound healing or suture removal.Timepoint: 7, 14, 30 days—

Countries

India

Contacts

Public ContactDr Raja Purushothaman J

Saveetha Medical College and Hospital

drbone04@gmail.com9840778281

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026