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A study to find out if a prehabilitation program with exercise, nutrition, and mental preparation before major cancer surgery helps cancer patients recover faster and have fewer complications compared to standard care.

Impact of Enhanced Prehabilitation on Postoperative Outcomes in Major Oncological Surgeries: A Randomized Controlled Trial - PREP-CANCER

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/01/0102644
Enrollment
324
Registered
2026-01-30
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C00-D49- Neoplasms Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Enhanced Prehabilitation group: Patients will receive standard prehabilitation plus resistance training, aerobic exercises, handgrip strengthening, and meditation. Exercise and Physioth
minimum 5 reps, maximum 10 per set). Quadriceps Strengthening: 3 sets of 10 repetitions per leg. Lower Leg Strengthening: 3 sets of 10 repetitions targeting the calf and anterior compartment muscles.

Sponsors

Dr Gunasekhar Vamsi Krishna
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients (greater than 18 years) undergoing primary Head and neck, Thoracic, Abdominal and Pelvic oncologic surgery. Histopathologically confirmed malignancies requiring surgical intervention.

Exclusion criteria

Exclusion criteria: Patients undergoing palliative surgery or non-curative resections. Patients with pre-existing bone diseases, and neuromuscular disorders affecting muscle function., heart dysfunction, liver dysfunction, renal dysfunction. Severe renal or hepatic dysfunction affecting metabolism and muscle mass. Patients who decline consent. Patients with recurrent and metastatic disease. Patients with age greater than 75 years

Design outcomes

Primary

MeasureTime frame
Postoperative complications according to Clavien-Dindo Classification Timepoint: 30 days post operative period

Secondary

MeasureTime frame
ICU and hospital stays Timepoint: till discharge from hospital;Nutritional and muscle statusTimepoint: 30 days postoperative period

Countries

India

Contacts

Public ContactDr Hemant Kumar Singh

AIIMS Mangalagiri

hemant.surgicaloncology@aiimsmangalagiri.edu.in8903306321

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026