Health Condition 1: F039- Unspecified dementia
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Sponsors
Dr Abraham Paulose
Eligibility
Inclusion criteria
Inclusion criteria: 1) Individuals aged 60 years and above 2) Participants diagnosed with dementia 3) Individuals who provide informed consent 4) Willingness to undergo relevant blood tests, which includes serum homocysteine measurement and other required investigations (e.g., vitamin B12, folate, etc.).
Exclusion criteria
Exclusion criteria: 1) Cognitively normal elderly individuals 2) Patients with CKD/ Dialysis as it can affect the serum homocysteine levels. 3) Patients with Vegetarian diet-As it can cause Vitamin B12 deficiency which influence serum homocysteine levels. 4) Malignancy. 5) Hypothyroidism. 6) Patient under vitamin supplements especially vitamin B12 as it caninfluence serum homocysteine levels. 7) Individuals with acute or chronic psychiatric illnesses other than dementia which includes schizophrenia, major depressive disorder, bipolar disorder. 8) Smoking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To explore the potential of serum homocysteine as a biochemical indicator assessed once at the time of participant recruitment associated to cognitive decline in the elderly, with the aim of identifying individuals who may be at increased risk for developing dementia.Timepoint: single time point at recruitment | — |
Secondary
| Measure | Time frame |
|---|---|
| To analyze the connection between circulating homocysteine levels assessed once at the time of participant recruitment & the extent of cognitive impairment, based on standardized neurocognitive evaluation tools such as the Mini-Mental State Examination (MMSE)Timepoint: single time point at recruitment | — |
Countries
India
Contacts
Public ContactDr Abraham Paulose
Vinayaka Missions Kirupananda Variyar Medical College & Hospital, Salem
Outcome results
None listed