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How Disrupted Sleep Wake Body Clock Cycle Affects Outcomes in Severe Infection

Association Between Circadian Rhythm Dysfunction and Clinical Outcome in Adult Patients with Sepsis & Septic Shock - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/12/099947
Enrollment
110
Registered
2025-12-29
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A499- Bacterial infection, unspecified

Interventions

Intervention1: Nil: Nil

Sponsors

Dr. Souvik Maitra
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult critically ill patients with a diagnosis of sepsis as per sepsis-3 criteria.

Exclusion criteria

Exclusion criteria: 1. Patients refusal 2. Pregnancy 3. Patients not expected to survive beyond 48hrs

Design outcomes

Primary

MeasureTime frame
4.Association between circadian rhythm measured by amplitude of serum melatonin level variations at day 1-2 of illness and lymphocyte trajectoryTimepoint: 28 day—

Secondary

MeasureTime frame
1. Association between circadian rhythm measured by amplitude of serum melatonin level variations at day 6- 7 days of illness and hospital mortalityTimepoint: 28- day;Association between circadian rhythm measured by amplitude of serum melatonin level variations at day 1-2 of illness and PICSTimepoint: 28- day;Association between circadian rhythm measured by amplitude of serum melatonin level variations at day 1-2 of illness and delirium within 14 days of ICU admissionTimepoint: 28- day—

Countries

India

Contacts

Public ContactDr Souvik Maitra

All India Institute of Medical Sciences, New Delhi

souvikmaitra@live.com8146727891

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026