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Comparing two methods of adjusting breathing machine support in ICU patients with respiratory problems, to understand which leads to better weaning off process and thus better outcome

To Compare Pressure Support Adjustments Using Diaphragmatic Thickness Fraction And Conventional Method In Patients With Respiratory Distress On Mechanical Ventilation Admitted In ICU: A Randomized Controlled Trial. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/12/099945
Enrollment
78
Registered
2025-12-29
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C710- Malignant neoplasm of cerebrum, except lobes and ventricles Health Condition 2: S064- Epidural hemorrhage Health Condition 3: S065- Traumatic subdural hemorrhage Health Condition 4: S398- Other specified injuries of abdomen, lower back, pelvis and external genitals Health Condition 5: O152- Eclampsia complicating the puerperium Health Condition 6: D649- Anemia, unspecified Health Condition 7: K564- Other impaction of intestine Health Condition 8: K565- Intestinal adhesi

Interventions

Intervention1: NA: NA Intervention2: NOT APPLICABLE: NOT APPLICABLE Intervention3: NA: NA Control Intervention1: changing setting of the ventilator based on two different methods: Adjusting pressure s

Sponsors

Uttar Pradesh University of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult patients (18-60 years) on pressure support mechanical ventilation in ICU. 2. Respiratory distress using RDOS (Respiratory Distress Observational scale) more than 3 (corresponding with DTF less than 30 and RSBI more than 105 as per previous studies). 3. Post operative & Trauma patients needing elective ventilation

Exclusion criteria

Exclusion criteria: 1. Patients with acute or chronic lung pathology. 2. Patients having neuromuscular disorder. 3. Cardiac arrest or hemodynamic instability. 4. Transfer to another ward or hospital during study. 5. Withdrawal of consent or inability to complete study protocol.

Design outcomes

Primary

MeasureTime frame
This study aims to compare Pressure support adjustments using Diaphragmatic Thickness Fraction and Conventional Methods in Patients with Respiratory Distress on Mechanical Ventilation admitted in ICUTimepoint: measure starts as soon as the patient enters the icu and taken on mechanical ventilation which is taken as 0min then 15min, 30min, 45min, 60min, 75min, 90min, 105min, 120min.—

Secondary

MeasureTime frame
1. To compare the patient ventilator synchrony in both the groups. 2. To compare earliest time taken to achieve relief from respiratory distress in both the groups. 3. To compare hemodynamic parameters in both the groups. 4. To see the feasibility & reproducibility of implementing DTF-guided pressure support adjustments in routine clinical practice compared to conventional method Timepoint: Measurement will begin from the point patient is admitted in the icu & put on mechanical ventilation 0min then 15min, 30min, 45min, 60min, 75min, 90min, 105min, 120min.—

Countries

India

Contacts

Public ContactDr Prashant Kumar Mishra

Uttar Pradesh university of medical sciences

drprashant.mishra@yahoo.com9455677608

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026