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A study comparing anaesthesia with and without opioids on memory and thinking ability after surgery in elderly patients.

COMPARATIVE STUDY OF THE EFFECTS OF OPIOID BASED AND OPIOID FREE ANAESTHESIA ON POSTOPERATIVE COGNITIVE FUNCTIONS IN ELDERLY PATIENTS UNDERGOING MAJOR ABDOMINAL SURGERIES. A RANDOMISED CONTROLLED TRIAL. - NIL

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/12/099943
Enrollment
70
Registered
2025-12-29
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K928- Other specified diseases of the digestive system

Interventions

Intervention1: Injection Dexmeditomidine in General anaesthesia.: Giving Dexmeditomidine as premedication instead of Fentanyl and accessing its effects on post operative cognitive functions. Control I

Sponsors

KAHER, JNMC BELAGAVI.
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient age group 65 years to 90 years of either gender. Patient undergoing elective major abdominal surgeries under general anaesthesia. ASA physical status one and two.

Exclusion criteria

Exclusion criteria: Patients refusal Known alzheimers disease or dementia Neurobehavioral disorders Past history of stroke Known psychiatric illness BMI more than 30 History of chronic renal or hepatic disease Drug or alcohol abuse and Patients on opioid medication for pain management.

Design outcomes

Primary

MeasureTime frame
opioid free anaesthesia has less effects than opioid based anaesthesia on post operative cognitive functions.Timepoint: MOCA test On the day before surgery, On the morning of surgery before procedure, 6 hours after surgery, 24 hours after surgery, At the time of discharge.

Secondary

MeasureTime frame
post operative pain severity has effects on post operative cognitive functions.Timepoint: On the day before surgery, On the morning of surgery before procedure, 6 hours after surgery, 24 hours after surgery, At the time of discharge.

Countries

India

Contacts

Public ContactTharun J

KAHER JNMC Belagavi

tharunjayashankar@rediffmail.com9600823192

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026