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Using an eye test (PVEP) to detect early nerve damage in people with diabetes

Utility of pattern visual evoked potentials (PVEP) in detecting early neurodegenerative changes in diabetic patients - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/12/099925
Enrollment
75
Registered
2025-12-29
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H475- Disorders of other visual pathways

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil

Sponsors

P.Sai Harshitha
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Group one will include healthy individuals with no history of diabetes, ocular disease, neurological disorders, or any history of eye surgery or trauma. Group two will include individuals diagnosed with Type one or Type two diabetes mellitus without any clinical signs of diabetic retinopathy on dilated fundus examination. Group three will include individuals diagnosed with Type one or Type two diabetes mellitus who have non proliferative diabetic retinopathy.

Exclusion criteria

Exclusion criteria: Individuals with proliferative diabetic retinopathy. Individuals with neurological disorders that affect the visual pathway. Individuals with media opacities such as cataract or corneal opacity that interfere with visual evoked potential recording. Individuals taking medications that can alter visual evoked potential results. Individuals with systemic illnesses, other than diabetes in groups two and three, that can affect the visual pathway.

Design outcomes

Primary

MeasureTime frame
To assess P100 latency(ms) changes on pattern visual evoked potentials in diabetic patients and compare with healthy controls at baseline(single visit)Timepoint: Single time point at baseline

Secondary

MeasureTime frame
To evaluate P100 amplitude differences among groups at baseline To correlate P100 latency and amplitude with HBA1c measured within 3 months of assessment To correlate P100 abnormalities with duration of diabetesTimepoint: Single time point at baseline

Countries

India

Contacts

Public ContactU Vivekanand

Alluri Sita Ramaraju Academy of Medical Sciences

vivekanandu@gmail.com8333044920

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026