A Study comparing two steroid medicines Hydrocortisone or Dexamethasone for treating patients with severe Pneumonia

Comparative Efficacy and Safety of Hydrocortisone vs Dexamethasone in Severe Community Acquired Pneumonia: A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/099899

Enrollment

126

Registered

2025-12-29

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J189- Pneumonia, unspecified organism

Interventions

Intervention1: DEXAMETHASONE: In patients with Severe Community Acquired Pneumonia randomized to intervention arm Dexamethasone 7.5 mg IV would be given as Early as possible.This treatment with dexame

Eligibility

Inclusion criteria

Inclusion criteria: Patients with Severe Community Acquired Pneumonia as per Infectious Disease Society Of America Guidelines

Exclusion criteria

Exclusion criteria: 1 Viral pneumonia 2 Chronic use of steroids 3 Pregnant women 4 Patients who have DNR order 5 Viral hepatitis 6 Active Herpes infection 7 Active TB 8 Fungal Pneumonia 9 Myelosupression 10 Active upper GI Bleeding 11 Diabetic Ketoacidosis 12 Hyperosmolar Hyperglycemic state 13 Hypersensitivity to steroids

Design outcomes

Primary

Measure	Time frame
Comparing the length of Hospital stay Between Hydrocortisone vs Dexamethasone in Patients with Severe Community Acquired PneumoniaTimepoint: at the end of 8 days of treatment, day28 and day60	—

Secondary

Measure	Time frame
Requirement of Mechanical Ventilation and/or duration of Mechanical VentilationTimepoint: duration till discharge from hospital or till death in hospital;Side effects of steroids in terms of Hyperglycemia, Hospital Acquired Infection, Gastro Intestinal Bleeding and dyselectrolemiaTimepoint: duration till discharge from hospital or till death in hospital;All-Cause mortality on Day 28 and 60Timepoint: day 28 and day 60 from hospital admission;Requirement of Vasopressors and/or duration of Vasopressor Timepoint: duration till discharge from hospital or till death in hospital;Requirement of Non Invasive Ventilation and/or duration of Non Invasive VentilationTimepoint: duration till discharge from hospital or till death in hospital	—

Measure

Time frame

Requirement of Mechanical Ventilation and/or duration of Mechanical VentilationTimepoint: duration till discharge from hospital or till death in hospital;Side effects of steroids in terms of Hyperglycemia, Hospital Acquired Infection, Gastro Intestinal Bleeding and dyselectrolemiaTimepoint: duration till discharge from hospital or till death in hospital;All-Cause mortality on Day 28 and 60Timepoint: day 28 and day 60 from hospital admission;Requirement of Vasopressors and/or duration of Vasopressor Timepoint: duration till discharge from hospital or till death in hospital;Requirement of Non Invasive Ventilation and/or duration of Non Invasive VentilationTimepoint: duration till discharge from hospital or till death in hospital

—

Countries

India

Contacts

Public ContactDr Mahima Reddy

AIIMS New Delhi

rakeshyadav123@yahoo.com9868026888

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026