Comparison of two platelet-based treatments on pain, swelling,mouth opening and healing after lower wisdom tooth removal.

A comparison of the efficacy of advanced platelet-rich fibrin and leukocyte platelet-rich fibrin on postoperative pain, swelling, trismus, and soft tissue wound healing after removal of impacted mandibular third molar: A randomized controlled trial. - NIL

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/099872

Enrollment

144

Registered

2025-12-29

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: Advanced Platelet-Rich Fibrin: Advanced platelet-rich fibrin is a second-generation autologous platelet concentrate prepared using lower centrifugal forces (approximately 1500 rpm for 1

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients between age of 18-45 years of both genders. 2. Patients indicated for surgical removal of moderately difficult impacted mandibular third molar as per Modified Pederson s Index. 3. Healthy patients falling under ASA I and ASA II 4. Subjects able and willing to provide written informed consent and compliant with study procedure.

Exclusion criteria

Exclusion criteria: 1. Patients with mouth opening less than 30mm. 2. Patient with allergy with NSAIDS. 3. Patients having history of drug abuse. 4. Patients having any systemic or local immunodeficiency. 5. Patient is under regular analgesics and anti-depressants. 6. Having any blood coagulation impairment. 7. Presence of any acute oral infection. 8. Have been suffering with uncontrolled diabetes or other systemic diseases. 9. Having previous history of radiation therapy in the head and neck region. 10. Pregnant and nursing women. 11. Patient with the history of smoking and alcohol. 12. Soft tissue impactions.

Design outcomes

Primary

Measure	Time frame
Post operative pain intensity following impacted mandibular third molar removal measured by visual analogue scale.Timepoint: post operative 1st,3rd,7th and 15th day.	—

Secondary

Measure	Time frame
Post operative trismus measured by interincisal distance by vernier calliper.Timepoint: Post operative 1st,3rd,7th and 15th day.;Post operative swelling measured by Laskin method.Timepoint: post operative 1st,3rd,7th and 15th day.;Post operative soft tissue wound healing measured by criteri given by Landry et al.Timepoint: post operative 1st,3rd,7th and 15th day.	—

Countries

India

Contacts

Public ContactDr Jyotsna

Geetanjali Dental and Research Institute

drshallu23@yahoo.com9116155666

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026