A Study Comparing Dexmedetomidine, Lignocaine, and Air Used to Inflate the Breathing Tube Balloon and Their Effect on Comfort During Removal After Anesthesia

Comparison of Endotracheal Tube Cuff Inflation Between Dexmedetomidine, 2% Lignocaine and Air on Quality of Extubation: A Prospective Randomised Controlled Study. - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/099825

Enrollment

Registered

2025-12-24

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Dexmedetomidine: Endotracheal tube cuff inflated with 1mcg/kg of Dexmedetomidine diluted to 4-6ml with normal saline at intubation and extubation quality is assessed Control Interventio

Eligibility

Inclusion criteria

Inclusion criteria: Written and valid informed consent. Estimated duration of surgery more than 60 min and less than 300 min. ASA classes I and II Body mass index (BMI) less than 30 kg/m2. Elective surgeries

Exclusion criteria

Exclusion criteria: Patient refusal ASA classes III and IV Chronic smokers laryngotracheal diseases/surgery Known allergy to study agents COPD, asthma, history of recent upper respiratory tract infection Requiring insertion of nasogastric tube Oro-pharyngeal airway introduced preoperatively Multiple intubation attempts Raised intracranial pressure, intraocular pressure History of gastric regurgitation Requiring rapid sequence induction Anticipated difficult airway Undergoing laparoscopic surgeries

Design outcomes

Primary

Measure	Time frame
To assess and compare post extubation cough response in different groups.Timepoint: TE time at extubation T1 1min after extubation T2 2min after extubation T5 5min after extubation T10 10 min after extubation T15 15 min after extubation T30 30 min after extubation T60 60 min after extubation T2h 2h after extubation T4h 4h after extubation T6h 6h after extubation T12h 12h after extubation T24h 24h after extubation	—

Measure

Time frame

To assess and compare post extubation cough response in different groups.Timepoint: TE time at extubation T1 1min after extubation T2 2min after extubation T5 5min after extubation T10 10 min after extubation T15 15 min after extubation T30 30 min after extubation T60 60 min after extubation T2h 2h after extubation T4h 4h after extubation T6h 6h after extubation T12h 12h after extubation T24h 24h after extubation

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Secondary

Measure	Time frame
a)To assess and compare postoperative sore throat in different groups. b) To assess and compare postoperative dysphagia in different groups. c) To assess and compare postoperative hoarseness of voice in different groups. d) To assess and compare peri-extubation hemodynamic parameters in different groups. e) Likert scale for patient satisfaction on Post op day 1 Timepoint: TE time at extubation T1 1min after extubation T2 2min after extubation T5 5min after extubation T10 10 min after extubation T15 15 min after extubation T30 30 min after extubation T60 60 min after extubation T2h 2h after extubation T4h 4h after extubation T6h 6h after extubation T12h 12h after extubation T24h 24h after extubation	—

Measure

Time frame

a)To assess and compare postoperative sore throat in different groups. b) To assess and compare postoperative dysphagia in different groups. c) To assess and compare postoperative hoarseness of voice in different groups. d) To assess and compare peri-extubation hemodynamic parameters in different groups. e) Likert scale for patient satisfaction on Post op day 1 Timepoint: TE time at extubation T1 1min after extubation T2 2min after extubation T5 5min after extubation T10 10 min after extubation T15 15 min after extubation T30 30 min after extubation T60 60 min after extubation T2h 2h after extubation T4h 4h after extubation T6h 6h after extubation T12h 12h after extubation T24h 24h after extubation

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Countries

India

Contacts

Public ContactDrHema Shubha Yadlapalli

Nizam s Institute of Medical Sciences

njonnavithula@gmail.com9849422749

Outcome results