Comparison between 1mcg/kg and 0.75mcg/kg dexmedetomidine given through nasal atomizer to adults undergoing elective surgery under general anaesthesia for smooth recovery from A anaesthesia at the end of surgery.

A comparative study to evaluate the efficacy of 1mcg/kg of dexmedetomidine Vs 0.75mcg/kg of dexmedetomidine given via nasal atomizer on the hemodynamic response among adult patients undergoing elective surgery. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/099802

Enrollment

Registered

2025-12-24

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intranasal dexmedetomedine 1mcg/kg, given through nasal atomizer: 1mcg/kg dexmedetomedine given via nasal atomizer one time administration, monitoring for hemodynamics done upto 2hrs af

Eligibility

Inclusion criteria

Inclusion criteria: patients undergoing elective surgery under general anaesthesia.

Exclusion criteria

Exclusion criteria: Patients posted for emergency surgery, patients requiring double lumen tube for intubation, patients with uncontrolled systemic illnesses

Design outcomes

Primary

Measure	Time frame
Efficacy of two doses of dexmedetomidine in attenuating hemodynamic response to intubationTimepoint: Efficacy of two doses of dexmedetomidine in attenuating hemodynamic response to intubation. Monitoring of hemodynamics done in the intraoperative period every 5minutes in the initial 30minutes, then every 30minutes till extubation. The same monitoring is then continued upto 2hrs un the post operative period.	—

Measure

Time frame

Efficacy of two doses of dexmedetomidine in attenuating hemodynamic response to intubationTimepoint: Efficacy of two doses of dexmedetomidine in attenuating hemodynamic response to intubation. Monitoring of hemodynamics done in the intraoperative period every 5minutes in the initial 30minutes, then every 30minutes till extubation. The same monitoring is then continued upto 2hrs un the post operative period.

—

Secondary

Measure	Time frame
Level of sedation Incidence of post operative nausea and vomiting Incidence of post operative sore throatTimepoint: For 2hours from the time of extubation	—

Countries

India

Contacts

Public ContactDr Bindu

Bangalore Medical College and Research Institute

vijaym.vm84@gmail.com08026701529

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026