To study if Oral Tranexamic acid given before birth can reduce blood loss during vaginal delivery in high risk women

Prophylactic Oral Tranexamic acid to reduce blood loss during vaginal delivery in high risk women - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/099772

Enrollment

400

Registered

2025-12-23

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O092- Supervision of pregnancy with other poor reproductive or obstetric history

Interventions

Intervention1: randomised controlled trial: The eligible women will be allocated to one of the 2 study groups: Group A (N=200) will receive oral tranexamic acid 1 gm at the end of first stage of labor

Eligibility

Inclusion criteria

Inclusion criteria: MODERATE AND SEVERE ANAEMIA GRAND MULTIPARA PROLONGED LABOR MULTIPLE PREGNANCY MACROSOMIA POLYHYDRAMNIOS PIH APH ABRUPTION UTERINE PATHOLOGY LIKE FIBROID THROMBOCYTOPENIA PPROM CHORIOAMNIONITIS Patient for TOLAC

Exclusion criteria

Exclusion criteria: Known allergy to Tranexamic acid Patient on LMWH or antiplatelet agent Medical past history of thromboembolism, autoimmune disease,sickle cell anaemia,bleeding disorders, renal disease,liver disease, known cardiovascular disease.

Design outcomes

Primary

Measure	Time frame
1.To study the efficacy of prophylactic oral Tranexamic acid as an adjunct to AMTSL in reducingblood loss at the time of placental separation and immediate post partum period upto 2 hours in high risk vaginal deliveries. 2. To determine the incidence of PPH in 2 groups (with and without oral Tranexamic acid).Timepoint: 2 hours post delivery	—

Secondary

Measure	Time frame
1. To study side effects of oral Tranexamic acid in the medication group.Timepoint: 2 hours post delivery	—

Countries

India

Contacts

Public ContactDR SONAL PRASAD

DR. BABA SAHEB AMBEDKAR HOSPITAL, ROHINI

heeragyanee@gmail.com8130940185

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026