Amisulpride,Dexamethasone and Ondansetron efficacy comparison for prevention of postoperative Nausea Vomitting.

Comparison of Efficacy of Amisulpride,Dexamethasone and Ondansetron for Prevention of Postoperative Nausea and Vomitting in Patients Undergoing Laparoscopic Abdominal Surgeries under General Anaesthesia. - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/12/099764

Enrollment

Registered

2025-12-23

Start date

Unknown

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Control Intervention1: Amisulpride: 5mg iv Amisulpride will be given to first group of patient intravenously once just before in

Eligibility

Inclusion criteria

Inclusion criteria: Patients scheduled for elective laparoscopic abdominal surgery under general anaesthesia ASA grade 1/2

Exclusion criteria

Exclusion criteria: Allergy to any of the study drug Currently recieving steroids or antiemetics Pregnant and lactating females Use of nitrous oxide as inhalational agent Use of propofol for TIVA Patients with BMI more than 35 History of drug abuse,psychiatric disorder,chronic pain History of gastro esophageal reflux disease

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of Amisulpride,Dexamethasone,Ondansetron for prevention of nausea and emesis postoperatively.Timepoint: After extubation 11 point nausea severity scoring will be assessed at 1hour,12hour,24hour postoperatively	—

Secondary

Measure	Time frame
Study severity of nausea Study number of episodes of emesis Compare time of first rescue antiemetic used Compare total consumption of antiemetics in first 48 hours postoperatively Comparision of occurence of any adverse events or QT prolongation in either group Compare patient satisfaction in each groupsTimepoint: After extubation 11 point nausea severity scoring will be assessed at 1hour,12hour,24hour postoperatively	—

Measure

Time frame

Study severity of nausea Study number of episodes of emesis Compare time of first rescue antiemetic used Compare total consumption of antiemetics in first 48 hours postoperatively Comparision of occurence of any adverse events or QT prolongation in either group Compare patient satisfaction in each groupsTimepoint: After extubation 11 point nausea severity scoring will be assessed at 1hour,12hour,24hour postoperatively

—

Countries

India

Contacts

Public ContactDr Kalpana Verma

Mahatma Gandhi Medical College And Hospital

kalpana2007.kv@gmail.com7727886029

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026