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To compare the effect of conventional local anaesthesia ,sodium bicarbonate buffered lignocaine and magnesium sulfate with lignocaine in inferior nerve block in patients with sumptomatic irreversible pulpitis.

Comparative Evaluation of Anaesthetic Efficacy of conventional Lignocaine, sodium Bicarbonate-Buffered Lignocaine, lignocaine with Magnesium Sulphate in Inferior Alveolar Nerve Block for Patients with Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial - CCT

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/12/099746
Enrollment
180
Registered
2025-12-23
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z758- Other problems related to medicalfacilities and other health care

Interventions

Intervention1: 8.4% sodium bicarbonate buffered lignocaine , lignocaine with 1% magnesium sulfate: .2 ml 8.4% sodium biarbonate will be mixed with 1.6ml lignocaine to prepared buffered lignocaine and

Sponsors

department of conservative dentistry and endodontics
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Lingering response to cold test, with prolonged response after the removal of the Endo-Ice cold spray stimuli (Roeko; Coltene Whaledent, Langenau, Germany). No radiographic alterations of the periodontal ligament space and fully formed roots (revealed by an intra-oral periapical radiograph). Patients in good health (ASA classification I).

Exclusion criteria

Exclusion criteria: Pregnant or nursing mothers, those with a contraindication for the use of magnesium sulphate, sodium bicarbonate. Those who are allergic to local anaesthetic, sodium bicarbonate or magnesium sulphate solution will be excluded. Patient has history of significant medical problem (ASA classification II, III or greater) Recent cardiac surgery Patient has taken CNS depressants or any analgesic within 6 hours prior to treatment Alcoholic, chronic smokers patients

Design outcomes

Primary

MeasureTime frame
To compare the anaesthetic efficacy of conventional lignocaine, lignocaine buffered with 8.4% sodium bicarbonate and lignocaine with 1% magnesium sulfate in Inferior alveolar nerve block for patients with symptomatic irreversible pulpitis.Timepoint: anaesthetic efficacy of conventional lignocaine,buffered lignocaine, magnesium sulfate with lignocaine will be assessed after 15 min of IANB at access preparation and canal insrumentations.

Secondary

MeasureTime frame
nillTimepoint:

Countries

India

Contacts

Public ContactMANJUKUMARI

jcd dental college

dr.manju063@gmail.com9996434553

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026