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Comparison of safety of two modes used by a ventilator to maintain breathing in patients undergoing lower spine surgery

Comparison of pressure controlled versus volume controlled ventilation modes in patients undergoing lumbar spine surgery in prone position - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/12/099742
Enrollment
60
Registered
2025-12-23
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nil: Nil Intervention2: Pressure Controlled Ventilation: Inspiratory pressure adjusted to achieve a tidal volume of 8 ml per kg maintaining end tidal carbon dioxide between 35 and 40 mm

Sponsors

Dr Anjali R Hegde
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients aged 18 to 70 years 2.ASA physical status 1 and 2 3.Scheduled for elective lumbar spine surgery requiring prone positioning 4.Informed written consent obtained

Exclusion criteria

Exclusion criteria: 1. ASA physical status 3 or above 2. Pre existing pulmonary disease 3. Significant cardiovascular disease 4. Obesity defined as BMI greater than 35 5. Emergency surgery 6. Severe hepatic or renal impairment

Design outcomes

Primary

MeasureTime frame
Pulmonary Mechanics measured as 1.Delivered tidal volume 2.Minute ventilation 3.Peak inspiratory pressure 4.Plateau pressure 5.End-tidal CO2Timepoint: Baseline, 10 minutes, 30 minutes, 60 minutes after prone positioning, Immediate postoperative period—

Secondary

MeasureTime frame
Hemodynamics measured as 1.Heart rate 2.Systolic BP 3.Diastolic BP 4.Mean arterial pressureTimepoint: Baseline, 10 minutes, 30 minutes, 60 minutes after prone positioning, Immediate postoperative period;Stress response measured as Glucose Random Blood SugarTimepoint: Baseline, 10 minutes, 30 minutes, 60 minutes after prone positioning, Immediate postoperative period;Oxygenation measured as 1.PaO2 2.PaCO2 3.pH 4.SpO2 Timepoint: Baseline, 10 minutes, 30 minutes, 60 minutes after prone positioning, Immediate postoperative period;Intraoperative blood loss measured as Suction Volume Minus Irrigation in ml plus Gauze Weight in gramsTimepoint: Baseline, 10 minutes, 30 minutes, 60 minutes after prone positioning, Immediate postoperative period—

Countries

India

Contacts

Public ContactDr Anjali R Hegde

Sri Siddhartha Medical College Tumkur

anjurh14@gmail.com9986994287

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026