Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium
Conditions
Interventions
Intervention1: Carbetocin Group: IV Carbetocin 100 mcg bolus over 1 minute
Control Intervention1: Oxytocin Group: IV Oxytocin 15 lU infusion over 20 minutes
Sponsors
Kasturba Medical College and Kasturba Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. ASA Physical Status I and II 2. Singleton pregnancy (after 37 weeks) 3. No history of hypertensive disorders or cardiovascular disease
Exclusion criteria
Exclusion criteria: 1. Preeclampsia or eclampsia 2. Known hypersensitivity to oxytocin or carbetocin 3. Multiple gestations 4. Placental abnormalities (placenta previa, placental abruption) 5. Severe anemia (Hb less than 7 gram percent) 6. Contraindications to spinal anesthesia (patient refusal, raised intracranial pressure, infection at the site of administration, hypersensitivity to local anaesthetic, coagulopathy, sepsis, uncorrected hypovolemia)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the hemodynamic effects (blood pressure, heart rate, and oxygen saturation) of intravenous oxytocin and carbetocin in patients undergoing cesarean section under spinal anesthesia.Timepoint: After delivery of the baby and clamping of the umbilical cord, patients will receive either oxytocin or carbetocin. Every 5 minutes for the first 30 minutes. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To assess the incidence of severe hypotension requiring vasopressor intervention. 2. To evaluate the need for additional uterotonic agents. 3. To analyze the frequency of adverse effects such as nausea, vomiting, dizziness, and chest discomfort. 4. To observe uterine tone response and blood loss estimation intraoperatively.Timepoint: Intraoperatively | — |
Countries
India
Contacts
Public ContactDr Greeshma Jose
Manipal Academy of Higher Education
Outcome results
None listed